CYTOCHALASIN D
- Product Name:CYTOCHALASIN D
- CAS:22144-77-0
- MF:C30H37NO6
- MW:507.62
- EINECS:244-804-1
- Mol File:22144-77-0.mol
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CYTOCHALASIN D Chemical Properties
- Melting point:255-260°C
- Boiling point:595.84°C (rough estimate)
- Density 1.1764 (rough estimate)
- refractive index 1.6310 (estimate)
- Flash point:87℃
- storage temp. −20°C
- solubility DMSO: soluble
- form White solid
- pka11.95±0.70(Predicted)
- BRN 1632828
- EPA Substance Registry SystemCytochalasin D (22144-77-0)
- Language:EnglishProvider:SigmaAldrich
CYTOCHALASIN D Usage And Synthesis
- Chemical PropertiesPowder
- UsesCytochalasin D acts as an anti-hypertensive drug acting on human intestinal epithelial caco-2 cells. Also has activity in HMG-CoA reductase inhibitors used in the lowering of cholesterol. Actin inhib itor, actin polymerization inhibitor affecting cell movement, growth, phagocytosis and even secretion.
- UsesCytochalasin D is the most studied of the cytochalasins. Like most of the members of this mycotoxin class, cytochalasin D exhibits potent inhibition of actin filament function leading to cell death by apoptosis. This led to early investigation of the metabolite as an antitumour agent. Cytochalasin D has become one of the standard cellular probes for investigating the role of actin in cell biology.
- UsesA cell cycle arresting compound used in actin polymerization studies and cytological research
- DefinitionChEBI: An organic heterotricyclic compound that is a mycotoxin produced by Helminthosporium and other moulds which is cell permeable and a potent inhibitor of actin polymerisation and DNA synthesis.
- General DescriptionNeedles or fluffy white powder.
- Reactivity ProfileCYTOCHALASIN D may be sensitive to exposure to heat. CYTOCHALASIN D can react with strong oxidizing agents, strong acids and strong bases. .
- Fire HazardFlash point data for CYTOCHALASIN D are not available; however, CYTOCHALASIN D is probably combustible.
- Biological ActivityPotent disruptor of actin filament function. Alters tight junction permeability. Unlike cytochalasin B, does not inhibit monosaccharide transport across the plasma membrane.
- Safety ProfilePoison by ingestion, subcutaneous, and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
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