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CYTOCHALASIN D

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CYTOCHALASIN D Basic information
CYTOCHALASIN D Chemical Properties
  • Melting point:255-260°C
  • Boiling point:595.84°C (rough estimate)
  • Density 1.1764 (rough estimate)
  • refractive index 1.6310 (estimate)
  • Flash point:87℃
  • storage temp. −20°C
  • solubility DMSO: soluble
  • form White solid
  • pka11.95±0.70(Predicted)
  • BRN 1632828
  • EPA Substance Registry SystemCytochalasin D (22144-77-0)
Safety Information
  • Hazard Codes T
  • Risk Statements 25-63
  • Safety Statements 36/37-45
  • RIDADR UN 1544 6.1/PG 2
  • WGK Germany 3
  • RTECS GZ4850000
  • HazardClass 6.1(a)
  • PackingGroup I
  • HS Code 29337900
MSDS
CYTOCHALASIN D Usage And Synthesis
  • Chemical PropertiesPowder
  • UsesCytochalasin D acts as an anti-hypertensive drug acting on human intestinal epithelial caco-2 cells. Also has activity in HMG-CoA reductase inhibitors used in the lowering of cholesterol. Actin inhib itor, actin polymerization inhibitor affecting cell movement, growth, phagocytosis and even secretion.
  • UsesCytochalasin D is the most studied of the cytochalasins. Like most of the members of this mycotoxin class, cytochalasin D exhibits potent inhibition of actin filament function leading to cell death by apoptosis. This led to early investigation of the metabolite as an antitumour agent. Cytochalasin D has become one of the standard cellular probes for investigating the role of actin in cell biology.
  • UsesCytochalasin D is the most studied of the cytochalasins. Like most of the members of this mycotoxin class, cytochalasin D exhibits potent inhibition of actin filament function leading to cell death by apoptosis. This led to early investigation of the metabolite as an antitumor agent. Cytochalasin D has become one of the standard cellular probes for investigating the role of actin in cell biology.
  • UsesA cell cycle arresting compound used in actin polymerization studies and cytological research
  • DefinitionChEBI: An organic heterotricyclic compound that is a mycotoxin produced by Helminthosporium and other moulds which is cell permeable and a potent inhibitor of actin polymerisation and DNA synthesis.
  • General DescriptionNeedles or fluffy white powder.
  • Reactivity ProfileCYTOCHALASIN D may be sensitive to exposure to heat. CYTOCHALASIN D can react with strong oxidizing agents, strong acids and strong bases. .
  • Fire HazardFlash point data for CYTOCHALASIN D are not available; however, CYTOCHALASIN D is probably combustible.
  • Biological ActivityPotent disruptor of actin filament function. Alters tight junction permeability. Unlike cytochalasin B, does not inhibit monosaccharide transport across the plasma membrane.
  • Safety ProfilePoison by ingestion, subcutaneous, and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
CYTOCHALASIN D(22144-77-0)Related Product Information
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