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CYTOCHALASIN D

$ 1.00 /1kg

Min. Order1g
Purity99%
Cas No 22144-77-0
Supply Ability100KG
Update time2019-07-06

career henan chemical co

career henan chemical co

6YR

China

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Chemical Properties

Product Name	CYTOCHALASIN D
CAS No	22144-77-0
EC-No
Min. Order	1g
Purity	99%
Supply Ability	100KG
Release date	2019/07/06

CYTOCHALASIN D Basic information

Product Name:	CYTOCHALASIN D
Synonyms:	ZYGOSPORIN A;CYTOCHALASIN D;CYTOCHALASIN D, ZYGOSPORIUM MANSONII;CYTOCHALASIN D, ZYGUSPORIUM MANSONII;(7S,13E,16S,18R,19E,21R)-21-(ACETYLOXY)-7,18-DIHYDROXY-16,18-DIMETHYL-10-PHENYL[11]CYTOCHALASA-6(12),13,19-TRIENE-1,17-DIONE;(11)cytochalasa-6(12),13,19-triene-1,17-dione,21-(acetyloxy)-7,18-dihydroxy-16;,12,15-decahydro-6,12,15-trihydroxy-4,10,12-trimethyl-5-methylene-,15-acetate;,18-dimethyl-10-phenyl-,(7s,13e,16s,18r,19e,21r)-
CAS:	22144-77-0
MF:	C30H37NO6
MW:	507.62
EINECS:	244-804-1
Product Categories:	Caspases/Apoptosis;antibiotic
Mol File:	22144-77-0.mol

CYTOCHALASIN D Chemical Properties

Melting point	255-260°C
Boiling point	595.84°C (rough estimate)
density	1.1764 (rough estimate)
refractive index	1.6310 (estimate)
Fp	87℃
storage temp.	−20°C
solubility	DMSO: soluble

Safety Information

Hazard Codes	T
Risk Statements	25-63
Safety Statements	36/37-45
RIDADR	UN 1544 6.1/PG 2
WGK Germany	3
RTECS	GZ4850000
HazardClass	6.1(a)
PackingGroup	I

MSDS Information

Provider	Language
SigmaAldrich	English

CYTOCHALASIN D Usage And Synthesis

Chemical Properties	Powder
Uses	Cytochalasin D acts as an anti-hypertensive drug acting on human intestinal epithelial caco-2 cells. Also has activity in HMG-CoA reductase inhibitors used in the lowering of cholesterol. Actin inhib itor, actin polymerization inhibitor affecting cell movement, growth, phagocytosis and even secretion.
Uses	Cytochalasin D is the most studied of the cytochalasins. Like most of the members of this mycotoxin class, cytochalasin D exhibits potent inhibition of actin filament function leading to cell death by apoptosis. This led to early investigation of the metabolite as an antitumour agent. Cytochalasin D has become one of the standard cellular probes for investigating the role of actin in cell biology.
Uses	Cytochalasin D is the most studied of the cytochalasins. Like most of the members of this mycotoxin class, cytochalasin D exhibits potent inhibition of actin filament function leading to cell death by apoptosis. This led to early investigation of the metabolite as an antitumor agent. Cytochalasin D has become one of the standard cellular probes for investigating the role of actin in cell biology.
Uses	A cell cycle arresting compound used in actin polymerization studies and cytological research
Definition	ChEBI: An organic heterotricyclic compound that is a mycotoxin produced by Helminthosporium and other moulds which is cell permeable and a potent inhibitor of actin polymerisation and DNA synthesis.
General Description	Needles or fluffy white powder.
Reactivity Profile	CYTOCHALASIN D may be sensitive to exposure to heat. CYTOCHALASIN D can react with strong oxidizing agents, strong acids and strong bases. .
Fire Hazard	Flash point data for CYTOCHALASIN D are not available; however, CYTOCHALASIN D is probably combustible.
Biological Activity	Potent disruptor of actin filament function. Alters tight junction permeability. Unlike cytochalasin B, does not inhibit monosaccharide transport across the plasma membrane.
Safety Profile	Poison by ingestion, subcutaneous, and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

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