Strictosidinic acid

Product NameStrictosidinic acid
CAS150148-81-5
MFC26H32N2O9
MW516.54
EINECS
MOL File150148-81-5.mol

Chemical Properties

Boiling point	792.8±60.0 °C(Predicted)
Density	1.50±0.1 g/cm3(Predicted)
storage temp.	4°C, stored under nitrogen
pka	4.67±0.70(Predicted)
form	Solid
color	Light yellow to yellow

Usage And Synthesis

Uses

Strictosidinic acid, an orally active glycoside indole monoterpene alkaloid isolated from Psychotria myriantha leaves, inhibits precursor enzymes of 5-HT biosynthesis and reduces the 5-HT levels. Strictosidinic acid has peripheral analgesic and antipyretic activities in mice[1][2].

Biological Activity

Strictosidinic acid, an glycosidic indole monoterpene alkaloid isolated from the leaves of Psychotria myriantha, inhibits the precursor enzymes of 5-HT biosynthesis and reduces 5-HT content. It has peripheral analgesic and antipyretic activity in mice.

in vivo

Strictosidinic acid (20 μg/μl; intra-hippocampal injection) causes a significance of 83.5% reduction in 5-HT levels. Strictosidinic acid (10 mg/kg; ip) causes a 63.4% reduction in 5- HT levels and a 67.4% reduction in DOPAC values in male Wistar rats, weighing 200-250 g.

target

5-HT Receptor

IC 50

5-HT Receptor

References

[1] F M Farias, et al. Strictosidinic Acid, Isolated From Psychotria Myriantha Mull. Arg. (Rubiaceae), Decreases Serotonin Levels in Rat Hippocampus. Fitoterapia. 2012 Sep;83(6):1138-43. DOI:10.1016/j.fitote.2012.04.013
[2] F M Farias, et al. Monoamine Levels in Rat Striatum After Acute Intraperitoneal Injection of Strictosidinic Acid Isolated From Psychotria Myriantha Mull. Arg. (Rubiaceae). Phytomedicine. 2010 Mar;17(3-4):289-91. DOI:10.1016/j.phymed.2009.05.008