β-Eudesmol is a sesquiterpenoid molecule that affects the central nervous system (CNS). It is known to induce neurite outgrowth. Antiangiogenic activity.
ChEBI: A carbobicyclic compound that is trans-decalin substituted at positions 2, 4a, and 8 by 2-hydroxypropan-2-yl, methyl and methylidene groups, respectively (the 2R,4aR,8aS-diastereoisomer).
β-Eudesmol has many pharmacological benefits. It is an active ingredient present in many essential oils, showing antioxidant and antimicrobial activities. β-Eudesmol elicits its antifungal and anti-wood-decay fungal activities in leaf essential oil of Litsea coreana tree, and the twigs of Taiwania cryptomerioides trees respectively. It suppresses tumor cell proliferation, growth, and migration of human tumor cells. β-Eudesmol is known to have various protective effects on the nervous system.
Beta-Eudesmol (2.5-5 mg/kg; Intraperitoneal injection; Once daily for 7 days) significantly inhibits tumor cell and new blood vessel generation in MK mice[1].
Beta-Eudesmol (50-100 mg/kg; Intraperitoneal injection; Single dose) can inhibit the NF-κb signaling pathway and has anti-inflammatory and antioxidant effects in C57BL/6 mice[2].
| Animal Model: | Male KM mice model[1] |
| Dosage: | 1.25 mg/kg, 2.5mg/kg, 5 mg/kg |
| Administration: | Intraperitoneal injection (i.p.); Once daily for 7 days |
| Result: | Inhibited the growth of H22 tumor cells with inhibition rates of 39.9% (2.5 mg/kg) and 49.3%(5 mg/kg), respectively.
Inhibited the growth of S108 tumor cells with inhibition rates of 22.4% (2.5 mg/kg) and 42.2%(5 mg/kg), respectively.
Significantly decreased vascular index with inhibition rates of 34.4% (2.5 mg/kg) and 44.3% (5 mg/kg).
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| Animal Model: | Male C57BL/6 mice model[2] |
| Dosage: | 50 mg/kg, 100 mg/kg |
| Administration: | Intraperitoneal injection (i.p.); Single dose. 2 h before the cecal ligation and puncture (CLP) operation. |
| Result: | Increased the expression of TNF-α, IL-1β and IL-6 in a dose-dependent manner.
Increased the levels of superoxide dismutase (SOD) and glutathione (GSH), and decreased the levels of malondialdehyde (MDA) and myeloperoxidase (MPO).
Inhibit the phosphorylation of p65.
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