2,5-二氯-N-(2-甲基-4-硝基苯基)苯磺酰胺
2,5-二氯-N-(2-甲基-4-硝基苯基)苯磺酰胺
2,5-二氯-N-(2-甲基-4-硝基苯基)苯磺酰胺 性质
| 熔点 | 141-142℃ |
|---|---|
| 沸点 | 526.3±60.0 °C(Predicted) |
| 密度 | 1.566±0.06 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | DMSO：可溶，20mg/mL |
| 形态 | 黄色固体 |
| 酸度系数(pKa) | 5.83±0.10(Predicted) |
| 颜色 | 棕褐色 |
| 稳定性 | 可在-20°下的DMSO中的溶液保存长达2个月。 |
| InChIKey | AXNUEXXEQGQWPA-UHFFFAOYSA-N |
2,5-二氯-N-(2-甲基-4-硝基苯基)苯磺酰胺 用途与合成方法
|
PPAR
|
Wnt
|
β-catenin
|
FH535 is an inhibitor of Wnt/β-catenin and PPAR. FH535 inhibits PPARγ and PPARδ transactivation in HCT116 cells. FH535 (15 μM) activities depend on functional PPARδ but does not require a cysteine residue in the PPAR ligand-binding domain. FH535 inhibits recruitment of the coactivators GRIP1 and β-catenin to PPARδ and PPARγ. FH535 shows toxic effects on 12 carcinoma cell lines expressing wnt/β-catenin pathway. FH535 (20 μM) suppresses the β-catenin pathway in pancreatic cancer cells, and inhibits pancreatic cancer cell migration. Furthermore, FH535 (20, 40 μM) inhibits pancreatic cancer cell invasion and cell growth. FH535 represses angiogenesis-related genes in pancreatic cancer cells.
FH535 (25 mg/kg, i.p.) exhibits an anti-tumor effect on pancreatic cancer xenografts in mice. FH535 also represses angiogenesis in pancreatic cancer xenografts.
2,5-二氯-N-(2-甲基-4-硝基苯基)苯磺酰胺 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | HY-15721 | 1 mg | 174 | ||
| 2024-11-08 | HY-15721 | 5 mg | 348 |
