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(R)-(-)-3-Pyrrolidinol hydrochloride

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(R)-(-)-3-Pyrrolidinol hydrochloride Basic information
(R)-(-)-3-Pyrrolidinol hydrochloride Chemical Properties
  • Melting point:104-107 °C(lit.)
  • alpha -7.6°(20/D, c=3,5, CH3OH)
  • refractive index -7.8 ° (C=3.5, MeOH)
  • storage temp. Inert atmosphere,Room Temperature
  • solubility Soluble in DMSO.
  • optical activity[α]20/D 7.6°, c = 3.5 in methanol
  • BRN 4450078
  • InChIKeyQPMSJEFZULFYTB-PGMHMLKASA-N
  • CAS DataBase Reference104706-47-0(CAS DataBase Reference)
Safety Information
MSDS
(R)-(-)-3-Pyrrolidinol hydrochloride Usage And Synthesis
  • Chemical PropertiesLlight brown crystalline
  • Uses(R)-(-)-3-Pyrrolidinol hydrochloride is a chiral hydroxy derivative of pyrrlodine used in the preparation of chiral niologically active compounds such as muscarinic receptor antagonists and antimicrobial agents.
  • Uses(R)-3-Hydroxypyrrolidine hydrochloride is used as a darifenacin Intermediate.
  • Purification MethodsThe (±)-isomer is purified by repeated distillation ( b 102-104o/12mm, 108-110o/18mm), and the (±)-picrate crystallises from EtOH with m 140-141o. The R(+)-enantiomer has b 70o/0.6mm and [] D +5.6o (c 3.63, MeOH). Its hydrochloride has a negative rotation and its dimethiodide has m 230o and [] 24 -8.02o. [Suyama & Kanno Yakugaku Zasshi (J Pharm Soc Japan) 85 531 1965, Uno et al. J Heterocycl Chem 24 1025 1987, Flanagan & Joullie Heterocycles 26 2247 1987, Beilstein 21 III/IV 44.]
(R)-(-)-3-Pyrrolidinol hydrochloride Preparation Products And Raw materials
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