yellowish-white to yellow powder
An intermediate product of the metabolism of Folic Acid. This compound is a mixture of diastereomers.
Wellcovorin (GlaxoSmithKline).
human lymphoid cell lines were studied for leucovorin requirements to protect from methotrexate (mtx)-induced growth suppression. over a 72h continuous exposure leucovorin provided better protection to the cell lines laz-007 and raji than to the cell line
Folinic acid (7.0 mg/kg; intraperitoneal injection; every second day; for 3 weeks; Balb/c young growing male mice) treatment following methotrexate (MTX) administration appears to reverse this growth inhibition (Chronic administration of MTX induces suppression of skeletal growth in mice)[2].
| Animal Model: | 24 Balb/c young growing male mice aged 3 weeks (11.88 ± 0.25 g)[2] |
| Dosage: | 7.0 mg/kg |
| Administration: | Intraperitoneal injection; every second day; for 3 weeks |
| Result: | Following methotrexate (MTX) administration appears to reverse this growth inhibition.
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Human Endogenous Metabolite
