7-Aminoindole

• Fluorescent anion receptors and sensors
• Sulfate receptors
• Protein Kinase C θ (PKCθ) inhibitors
• Factor Xa Inhibitors
• Aurora kinase inhibitor
• Antagonist of Mineralocorticoid Receptor
• Potent histone deacetylase (HDAC) inhibitors
• TRPV1 antagonists
• Derivatives of N-(7-indolyl)benzenesulfonamide as cell cycle inhibitors

6960-42-5

5192-04-1

The general procedure for the synthesis of 7-aminoindoles using 7-nitroindoles as starting material is as follows: 7-nitroindoles were dissolved in ethanol according to the method described in Scheme VII (step A). To this solution was added ammonium formate (10 equivalents) and a catalytic amount of 10% palladium carbon. Subsequently, the reaction mixture was heated to reflux for 1 hour. Upon completion of the reaction, it was cooled to room temperature, filtered through a diatomaceous earth pad to remove the catalyst, and the filtrate was concentrated under reduced pressure to give 7-aminoindole in purple solid form in 99% yield.