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Doxifluridine

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Doxifluridine Basic information
Doxifluridine Chemical Properties
  • Melting point:188-192 °C(lit.)
  • alpha D25 +18.4° (c = 0.419 in water)
  • Density 1.3751 (estimate)
  • refractive index 20 ° (C=1, H2O)
  • storage temp. Inert atmosphere,Room Temperature
  • pka7.4(at 25℃)
  • Merck 14,3437
  • CAS DataBase Reference3094-09-5(CAS DataBase Reference)
Safety Information
  • Hazard Codes Xi
  • Risk Statements 36/37/38
  • Safety Statements 26-36-24/25
  • WGK Germany 2
  • RTECS YU7526000
  • Hazard Note Irritant
  • HazardClass IRRITANT, IRRITANT-HARMFUL
  • HS Code 29349990
  • ToxicityLD50 (14 day) in mice or rats (mg/kg): >1000 i.v.: >2000 s.c.; in male, female mice, male, female rats (mg/kg): >5000, >5000, 3471, 3390 orally (Shimizu)
MSDS
Doxifluridine Usage And Synthesis
  • DescriptionDoxifluridine is a prodrug derivative of 5-fluorouracil (5-FU). As an antineoplastic it is more potent than 5-FU in the treatment of breast, stomach, colon and rectal cancers.
  • Chemical PropertiesWhite Solid
  • OriginatorHoffmann-LaRoche (USA)
  • UsesA prodrug of 5-Flurouridine. A fluorinated pyrimidine nucleoside with cytostatic activity
  • UsesAn antitumor agent efficient in tumors, cell lines or in fibroblasts tranformed by H-ras or trk oncogenes. A metabolite of Capecitabine
  • Uses5’-Deoxy-5-fluorouridine is a metabolite of the chemotherapeutic agent Capecitabine (C175650). 5’-Deoxy-5-fluorouridine is an antitumor agent efficient in tumors, cell lines or in fibroblasts tranformed by H-ras or trk oncogenes.
  • Usesantineoplastic, pyrimidine antimetabolite
  • DefinitionChEBI: A pyrimidine 5'-deoxyribonucleoside that is 5-fluorouridine in which the hydroxy group at the 5' position is replaced by a hydrogen. It is an oral prodrug of the antineoplastic agent 5-fluorouracil. Designed to circumvent the rapid degradation of 5-fluoro racil by dihydropyrimidine dehydrogenase in the gut wall, it is converted into 5-fluorouracil in the presence of pyrimidine nucleoside phosphorylase.
  • brand nameFurtulon
Doxifluridine Preparation Products And Raw materials
Doxifluridine(3094-09-5)Related Product Information
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