Description
Doxifluridine is a prodrug derivative of 5-fluorouracil (5-FU). As an antineoplastic it is
more potent than 5-FU in the treatment of breast, stomach, colon and rectal cancers.
Chemical Properties
White Solid
Originator
Hoffmann-LaRoche (USA)
Uses
antineoplastic, pyrimidine antimetabolite
Uses
A prodrug of 5-Flurouridine. A fluorinated pyrimidine nucleoside with cytostatic activity
Uses
An antitumor agent efficient in tumors, cell lines or in fibroblasts tranformed by H-ras or trk oncogenes. A metabolite of Capecitabine
Uses
5’-Deoxy-5-fluorouridine is a metabolite of the chemotherapeutic agent Capecitabine (C175650). 5’-Deoxy-5-fluorouridine is an antitumor agent efficient in tumors, cell lines or in fibroblasts tranformed by H-ras or trk oncogenes.
Definition
ChEBI: A pyrimidine 5'-deoxyribonucleoside that is 5-fluorouridine in which the hydroxy group at the 5' position is replaced by a hydrogen. It is an oral prodrug of the antineoplastic agent 5-fluorouracil. Designed to circumvent the rapid degradation of 5-fluoro
racil by dihydropyrimidine dehydrogenase in the gut wall, it is converted into 5-fluorouracil in the presence of pyrimidine nucleoside phosphorylase.
Biochem/physiol Actions
Doxifluridine is an antitumor agent efficient in tumors, cell lines or in fibroblasts transformed by H-ras or trk oncogenes. Possesses anticachectic activity which is independent of its antiproliferative activity.
