1-Boc-5-aminoindole

166104-19-4

166104-20-7

General procedure for the synthesis of N-Boc-5-aminoindole from tert-butyl 5-nitro-1H-indole-1-carboxylate: tert-butyl 5-nitro-1H-indole-1-carboxylate (525 mg, 2.0 mmol) was dissolved in ethyl acetate (8 mL), and 10% palladium-carbon-catalyst (50 mg) was added. The reaction mixture was stirred overnight at room temperature in a hydrogen atmosphere. Upon completion of the reaction, the catalyst was removed by suction filtration and the filtrate was concentrated under reduced pressure to afford the white solid product N-Boc-5-aminoindole (469 mg, 100% yield).