5-Nitroindole

Yellow-Green Cyrstalline Solid, soluble in ethanol, diethyl ether, propylene glycol, petroleum ether and most non-volatile oils, insoluble in glycerol and mineral oils.

Reactant for preparation of:

• Pharmaceutically active 2-oxo-1-pyrrolidine analogues
• Tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles as potential anticancer immunomodulators
• Protein Kinase Inhibitors and antiproliferative agents
• Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4 (mGlu4)
• Antifungal agents
• Cannabinoid receptor type 1 (CB1) antagonists
• Potential anticancer agents
• Potential antivascular agents
• Selective Anti-leukemic agents
• Anti human immunodeficiency virus subtype 1 (HIV-1) agents

5-Nitroindole (cas# 6146-52-7) is a reagent involved in the synthesis of a variety of biochemical compounds, including: 2-oxo-1-pyrrolidine analogs, mGlu4 allosteric modulators, protein kinase inhibitors, antiproliferative agents, anti-HIV 1 agents, antifungal agents, anti-leukemic agents, antivascular agents, anticancer agents, and cannabinoid receptor type 1 (CB1) antagonists.

Decolourise (charcoal) 5-nitroindole and recrystallise it twice from aqueous EtOH or recrystallise it from octane. It has UV: 265 and 324nm (EtOH). [Beilstein 20 III/IV 3194, 20/7 V 41.]