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CYTIDINE 5'-DIPHOSPHOCHOLINE

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CYTIDINE 5'-DIPHOSPHOCHOLINE Basic information
CYTIDINE 5'-DIPHOSPHOCHOLINE Chemical Properties
  • alpha D25 +19.0° (c = 0.86 in H2O)
  • storage temp. Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
  • pka4.4(at 25℃)
  • CAS DataBase Reference987-78-0(CAS DataBase Reference)
Safety Information
  • ToxicityLD50 in mice, rats (mg/kg): 4600 ±335, 4150 ±370 i.v.; both species 8 g/kg orally (Grau)
CYTIDINE 5'-DIPHOSPHOCHOLINE Usage And Synthesis
  • OriginatorNicholin,Cyanamid,Italy,1971
  • Usesantidepressant, 5HT uptake inhibitor
  • Manufacturing ProcessA 250 ml conical flask containing 30 ml of a reaction liquor (pH 7.0) having a composition of 7.38 mg/ml of disodium salt of CMP (cytidine-5'- monophosphate), 24 mg/ml of choline, 10 mg/ml of glucose, 100 mg/ml of acetone-dried cells of Brevibacterium ammoniagenes ATCC 6872, 11.6 mg/ml of monopotassium phosphate, 20 mg/ml of dipotassium phosphate and 2.96 mg/ml of magnesium sulfate, (MgSO4·7H2O), was subjected to culturing at 30°C for 4 hours. Cytidine diphosphate choline was formed and accumulated at a concentration of 3.8 mg/ml in the culture liquor.
    The pH of 1.2 liters of filtrate containing 3.8 mg/ml of cytidine diphosphate choline, obtained by removing solid matters from the culturing liquor, was adjusted to a pH of 8.5 with a 0.5 N KOH solution. The filtrate was passed through a column of strongly basic anion exchange resin, Dowex 1 x 2 (formic acid type). After washing the resin with water, a formic acid solution was passed through the column with gradual increase in the concentration of formic acid (until 0.04 N max.). A fraction of cytidine diphosphate choline was collected by elution according to the so-called gradient elution method and absorbed onto carbon powders. Then, elution was effected with acetone, and the eluate was concentrated and dried. 1.3 g of cytidine diphosphate choline powders were obtained.
  • Therapeutic FunctionCerebral circulation stimulant
CYTIDINE 5'-DIPHOSPHOCHOLINE Preparation Products And Raw materials
CYTIDINE 5'-DIPHOSPHOCHOLINE(987-78-0)Related Product Information
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