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Cytosine Basic information
Cytosine Chemical Properties
  • Melting point:>300 °C (lit.)
  • Boiling point:208.2°C (rough estimate)
  • Density 0,48 g/cm3
  • refractive index 1.5000 (estimate)
  • storage temp. 2-8°C
  • solubility Clear to very slightly hazy colorless to faint yellow solution at 50 mg/ml in 0.5 M HCL.
  • form Crystalline Powder
  • pka4.60, 12.16(at 25℃)
  • color White to slightly yellow
  • Water Solubility soluble
  • Merck 14,2795
  • BRN 2637
  • Stability:Stable. Incompatible with strong oxidizing agents.
  • CAS DataBase Reference71-30-7(CAS DataBase Reference)
  • NIST Chemistry Reference2(1H)-Pyrimidinone, 4-amino-(71-30-7)
  • EPA Substance Registry System2(1H)-Pyrimidinone, 4-amino- (71-30-7)
Safety Information
  • Hazard Codes Xi,Xn
  • Risk Statements 36/37/38-20/21/22
  • Safety Statements 26-36-37/39
  • WGK Germany 1
  • RTECS UW7350150
  • Hazard Note Irritant
  • TSCA Yes
  • HS Code 29335910
Cytosine Usage And Synthesis
  • DescriptionCytosine is pyrimidine; along with adenine and guanine they account for the fi ve nucleic acid bases. Pyrimidines are heterocyclic single-ringed compounds based on the structure of pyrimidine. Cytosinelike adenine and guanine, form nucleosides and nucleotides in RNA and DNA. When the bases combine with ribose, a ribonucleoside forms; and when it attaches to deoxyribose, a deoxyribosenucleoside is formed. Names of the nucleoside are summarized in Table 29.1.these in turn combine with phosphoryl groups, in a process called phosphorylation, to form their respective nucleotides that form nucleic acids.the nucleotides can be tri, di, and mono phosphate nucleotides similar to the way in which adenine forms ATP, ADP, and AMP.
  • Chemical PropertiesWhite Solid
  • HistoryCytosine is first isolated by hydrolysis of calf thymus tissue by Albrecht Kossel (1853–1927) and A. Neumann during 1893–1894. Thymine’s structure was published in 1900 and confi rmed over the next several years when it was synthesized by several investigators. In 1903, cytosine was synthesized by Henry Lord Wheeler (1867–1914) and Treat B. Johnson, confirming its structure. Uracil was first isolated in 1900 from yeast nucleic acid found in bovine thymus and herring sperm.the methylation of uracil produces thymine; thymine is also called 5-methyluracil because methylation takes place at the fi fth carbon in uracil to produce thymine.
  • UsesWidely distributed in nature; constituent of nucleic acids
  • DefinitionChEBI: An aminopyrimidine that is pyrimidin-2-one having the amino group located at position 4.
  • DefinitionA nitrogenous base found in DNA and RNA. Cytosine has the pyrimidine ring structure.
  • Definitioncytosine: A pyrimidine derivative.It is one of the principal componentbases of nucleotides and the nucleicacids DNA and RNA.
  • Purification MethodsCytosine crystallises from H2O as the monohydrate which loses water on heating above 100o. Its solubility in H2O is 0.77%. UV: max 267nm ( 6,100) in H2O pH 8.8 and 275nm ( 10,400) in 0.1N HCl. [Hilbert & Johnson J Am Chem Soc 52 1152 1930, Hilbert et al. J Am Chem Soc 57 552 1935, Beistein 25 III/IV 3654.]
Cytosine Preparation Products And Raw materials
Cytosine(71-30-7)Related Product Information
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