Thiophene-2-sulfonamide

16629-19-9

6339-87-3

General procedure for the synthesis of 2-thiophenesulfonamide from 2-thiophenesulfonyl chloride: Example: preparation of 2-thiophenesulfonamide 2-Thiophenesulfonyl chloride (0.5 g, 2.74 mmol) was added to 25% ammonium hydroxide solution (5 mL, 33.45 mmol), refluxed and stirred at 50°C for 15 hours. Upon completion of the reaction, the reaction mixture was filtered while hot and the residue was washed with boiling aqueous 25% ammonium hydroxide solution. Subsequently, the ammonium hydroxide solution was removed by vacuum distillation until there was no ammonia odor. Eventually, 2-thiophenesulfonamide was recrystallized from water to give a white solid (0.328 g, 77% yield). Product Characterization: Melting point: 145-146°C; IR spectrum (KBr, cm1): 3290 (N-H stretching vibration), 3224 (N-H stretching vibration); NMR hydrogen spectrum (400 MHz, DMSO-d6, δ): 7.15 (1H, dd, J = 5.0, 3.7 Hz, C(4)H), 7.55 (1H, dd, J = 3.7, 1.4 Hz, C(3)H), 7.66 (2H, s, NH2), 7.85 (1H, dd, J = 5.0, 1.4 Hz, C(5)H); NMR carbon spectrum (100 MHz, DMSO-d6, δ): 127.3, 130.0, 131.1, 145.7; Mass spectrum (ESI): m/z 162 ([M-H] , 100%); High-resolution mass spectrum (ESI): C4H4NO2S2 ([M-H]) Calculated value 161.9689, measured value 161.9695.