ChemicalBook > Product Catalog > Pharmaceutical intermediates > Heterocyclic compound > Thiophene compounds > 2-Thiophenecarboxylic acid
2-Thiophenecarboxylic acid
- Product Name:2-Thiophenecarboxylic acid
- CAS:527-72-0
- MF:C5H4O2S
- MW:128.15
- EINECS:208-423-4
- Mol File:527-72-0.mol
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2-Thiophenecarboxylic acid Chemical Properties
- Melting point:125-127 °C(lit.)
- Boiling point:260 °C(lit.)
- Density 1.42
- refractive index 1.5160 (estimate)
- Flash point:259-261°C
- storage temp. Keep in dark place,Sealed in dry,Room Temperature
- form solid
- pka3.49(at 25℃)
- Water Solubility 80 g/L (20 ºC)
- Merck 14,9354
- BRN 110150
- InChIKeyQERYCTSHXKAMIS-UHFFFAOYSA-N
- CAS DataBase Reference527-72-0(CAS DataBase Reference)
- NIST Chemistry Reference2-Thiophenecarboxylic acid(527-72-0)
- EPA Substance Registry System2-Thiophenecarboxylic acid (527-72-0)
- Hazard Codes Xi
- Risk Statements 36/37/38
- Safety Statements 26-36-37/39
- WGK Germany 3
- RTECS XM8330200
- Hazard Note Irritant
- TSCA Yes
- HS Code 29349990
- Language:EnglishProvider:Thiophene-2-carboxylic acid
- Language:EnglishProvider:SigmaAldrich
- Language:EnglishProvider:ACROS
- Language:EnglishProvider:ALFA
2-Thiophenecarboxylic acid Usage And Synthesis
- Uses2-Thenoic Acid, is a sulfur-containing heterocyclic compound, used in the synthesis of pharmaceutical and biologically active compounds. It is also shown to be utilized by presumptive Rhodococcus bacterium in soil, as a sole source of carbon.
- Chemical Propertieswhite to light yellow crystal powder
- DefinitionChEBI: A thiophenecarboxylic acid in which the carboxy group is located at position 2.
- Synthesis Reference(s)The Journal of Organic Chemistry, 30, p. 3520, 1965 DOI: 10.1021/jo01021a055
- Purification MethodsCrystallise the acid from water and dry it in a vacuum. The amide has m 181o(from H2O) and pK2 5 10.54(50% aqueous dioxane). [Beilstein 18 H 289, 18 I 438, 18 II 269, 18 III/IV 4011, 18/6 V 158.]
2-Thiophenecarboxylic acid Preparation Products And Raw materials
- Preparation Products3-(THIOPHEN-2-YL)ISOXAZOL-5-AMINE3-BROMOTHIOPHENE-2-CARBOXAMIDE7-DIETHYLAMINO-3-THENOYLCOUMARINBIS(2-THIENYL) KETONE5-BROMOTHIOPHENE-2-CARBONITRILE2-THIOPHENAMINE5-TERT-BUTYL-THIOPHENE-2-CARBOXYLIC ACID5-Nitrothiophene-2-carboxylic acid5-Bromo-2-thiophenecarboxylic acid2-THIOPHENECARBOXYLIC ACID SODIUM SALT
- Rivaroxaban Impurity 34 Rivaroxaban Impurity 43 1H-ISOINDOLE-1,3(2H)-DIONE, 2-[(2R)-2-HYDROXY-3-[[4-(3-OXO-4-MORPHOLINYL)PHENYL]AMINO]PROPYL]- Rivaroxaban iMpurity 5 AcetaMide, N-[[(5S)-2-oxo-3-[4-(3-oxo-4-Morpholinyl)phenyl]-5-oxazolidinyl]Methyl]- Rivaroxaban Impurity 38 (S)-2-(3-chloro-2-hydroxypropyl)isoindoline-1,3-dione Rivaroxaban Impurity 44 Rivaroxaban Impurity 48 5-CHLOROTHIOPHENE-2-CARBOXYLIC ACID Rivaroxaban iMpurity 4 Rivaroxaban Impurity 52 4-(4-AMINOPHENYL)MORPHOLIN-3-ONE Urea, N,N'-bis[[(5S)-2-oxo-3-[4-(3-oxo-4-Morpholinyl)phenyl]-5-oxazolidinyl]Methyl]- Rivaroxaban Impurity 41 Rivaroxaban Impurity 45 (S)-2-(2-(5-chloro-N-(4-(5-((5-chlorothiophene-2-carboxamido)methyl)-2-oxooxazolidin-3-yl)phenyl)thiophene-2-carboxamido)ethoxy)acetic acid Rivaroxaban Impurity 53
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