Basic information Description References Safety Related Supplier
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LEE011

Basic information Description References Safety Related Supplier
LEE011 Basic information
LEE011 Chemical Properties
  • Boiling point:679.3±65.0 °C(Predicted)
  • Density 1.31±0.1 g/cm3(Predicted)
  • pka7.57±0.50(Predicted)
LEE011 Usage And Synthesis
  • DescriptionLEE011 (also known as ribociclib) is a CDK4/6 inhibitor. It has been recently approved by FDA (brand name: Kisqali®) to be combined with an aromatase inhibitor for initial endocrine-based therapy for treatment of postmenopausal women with hormone receptor positive, human epidermal growth factor receptor-2 negative (HR+/HER2-) advanced or metastatic breast cancer. It inhibits the growth of tumor cells by arresting the cells at the G1 checkpoint, which prevents the tumor cells from proliferating. In the phase III trial, it demonstrating statistically significant improvement in progression-free survival (PFS) compared to letrozole alone at the first pre-planned interim analysis. 
  • ReferencesS. Kim et al. "Abstract PR02: LEE011: An orally bioavailable, selective small molecule inhibitor of CDK4/6- Reactivating Rb in cancer." Molecular Cancer Therapeutics 12.11_Supplement (2013):PR02-PR02.
    Bardia, Aditya, et al. "Phase Ib/II study of LEE011, everolimus, and exemestane in postmenopausal women with ER+/HER2-metastatic breast cancer." Asco  2014.
    https://www.novartis.com/news/media-releases/novartis-kisqalir-ribociclib-lee011-receives-fda-approval-first-line-treatment
LEE011(1256963-02-6)Related Product Information
LEE011SupplierMore
  • Company Name:Wuhan NewBaiChuan Pharmaceutical Co., Ltd. Gold
  • Tel:027-50476178
  • Email:644526144@qq.com
  •  
  • Company Name:Shanghai Boyle Chemical Co., Ltd.
  • Tel:
  • Email:sales@boylechem.com
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  • Company Name:J & K SCIENTIFIC LTD.
  • Tel:400-666-7788 010-82848833-
  • Email:jkinfo@jkchemical.com;market6@jkchemical.com
  •  
  • Company Name:Jinan Trio PharmaTech Co., Ltd.
  • Tel:+86 (531) 88811783
  • Email:sales@trio-pharmatech.com (International market);trio@trio-pharmatech.com(Domestic market)
  •  
  • Company Name:Suzhou SuKaiLu Chemical Technology Co., Ltd.
  • Tel:+86-512-62766020 15995735907
  • Email:zwk@sukailu.com
  •