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Cabozantinib Malate

Basic information Pharmacological effects Precautions Safety Related Supplier
Cabozantinib Malate Basic information
Cabozantinib Malate Usage And Synthesis
  • Pharmacological effectsCabozantinib S-MALATE,formerly known as XL184, trade name Cabometyx, is developed by Exelixis biopharmaceutical company in the United States. The drug is mainly targeted at MET and VEGFR2 tyrosine kinases that associated with the growth and proliferation of prostate cancer, inhibiting tumor metastasis and angiogenesis. Cabozantinib S-MALATE , the malate of Cabozantinib, is an effective VEGFR2 inhibitor, and IC50 is 0.035 nM. It also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2 and AXL, and IC50 is 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM respectively.
    Cabozantinib(Cometriq) was granted orphan drug status by the U.S. Food and Drug Administration (FDA) in January 2011. Cabozantinib(Cometriq) is approved by the U.S. FDA for medullary thyroid cancer. and advanced renal cell carcinoma in people who have received prior anti-angiogenic therapy. It is currently undergoing clinical trials for the treatment of prostate, bladder, ovarian, brain, melanoma, breast, non-small cell lung, pancreatic, and hepatocellular cancers.
    Cabozantinib (S)-malate salt is a white to off-white solid that is practically insoluble in aqueous media.
  • PrecautionsCometriq has a boxed warning that increases the incidence of gastrointestinal perforation and fistula
    Formation and severe bleeding. If you have severe stomach pain, or if you feel that you are suffocating and vomiting while eating or drinking, call your doctor. Warnings and precautions include thrombosis events, Wound complications, hypertension, jaw osteonecrosis, palm-toe erythema paresthesia Syndrome (PPES), proteinuria and reversible posterior leukoencephalopathy syndrome (RPLS).
  • Chemical PropertiesOff-White Solid
  • UsesCabozantinib is a small molecule C-Met modulator. Cabozantinib acts as a potent multitargeted VEGFR2, Met, FLT3, Tie2, Kit and Ret inhibitor with IC50 of 0.035, 1.8, 14.4, 14.3 and 4.6 nM for VEGFR2, Met, FLT3, Tie2 and Kit, respectively. Cabozantinib shows dose-dependent inhibition of tumor growth and tumor regression, associated with disruption of the tumor vasculature and extensive tumor cell a poptosis.
  • UsesXL184 (Cabozantinib, BMS-907351) is a potent multitargeted VEGFR2, Met, FLT3, Tie2, Kit and Ret inhibitor with IC50 of 0.035, 1.8, 14.4, 14.3 and 4.6 nM for VEGFR2, Met, FLT3, Tie2 and Kit, respectively.
  • UsesCabozantinib malate is the malate of Cabozantinib, a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively.
  • DefinitionChEBI: A malate salt that is the mono-(S)-malate salt of cabozantinib. A multi-tyrosine kinase inhibitor, used for the treatment of progressive, metastatic, medullary thyroid cancer.
Cabozantinib Malate(1140909-48-3)Related Product Information
Cabozantinib MalateSupplierMore
  • Company Name:Hefei NaNo Biological Technology Co., Ltd. Gold
  • Tel:18010855303
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  • Products Intro:Product Name:CABOZANTINIB S-MALATE
    CAS:1140909-48-3
    Purity:99.5% Package:500g,1kg
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  • Products Intro:Product Name:Cabozantinib S-Malate
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    Purity:99.5% Package:100g;500g;1kg;5kg;10kg
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  • Products Intro:Product Name:Cabozantinib L-Malate
    CAS:1140909-48-3
    Purity:99.5 Package:1 g/;25 g/;100 g/;500 g/;1 KG/
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  • Company Name:Jurong Coupling Biotechnology Co., Ltd. Gold
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  • Products Intro:Product Name:Cabozantinib Malate
    CAS:1140909-48-3
    Purity:99 Package:20g Remarks:20g
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