Basic information Safety Related Supplier

EAI-045

Basic information Safety Related Supplier
EAI-045 Basic information
  • Product Name:EAI-045
  • CAS:1942114-09-1
  • MF:C19H14FN3O3S
  • MW:0
  • EINECS:
  • Mol File:Mol File
EAI-045 Chemical Properties
  • Density 1.546±0.06 g/cm3(Predicted)
  • pka7.20±0.50(Predicted)
EAI-045 Usage And Synthesis
  • DescriptionEAI045 is a potent and selective EGFR inhibitor (fourth generation). EAI045 targets selected drug-resistant EGFR mutants without affecting the wild-type receptor. EAI045 inhibits L858R/T790M-mutant EGFR with low-nanomolar potency in biochemical assays. Therefore, it is a potential candidate drug for the treatment of related non-small cell lung cancer (NSCLC). It should be noted that EAI-045 is effectively in targeting the EGFR C797S mutation, which is resistance to the third-generation EGFR inhibitors including AZD9291 (osimertinib) and CO-1686 (rociletinib).
  • ReferencesWang, S., Y. Song, and D. Liu. "EAI045: The fourth-generation EGFR inhibitor overcoming T790M and C797S resistance." Cancer Letters385(2017):51.
    Jia, Y., et al. "Overcoming EGFR T790M and C797S resistance with mutant-selective allosteric inhibitors:." Nature 534.7605(2016):129.
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