1,8-二羟基蒽醌
1,8-二羟基蒽醌 性质
熔点 | 191-193 °C (lit.) |
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沸点 | 342.92°C (rough estimate) |
密度 | 1.3032 (rough estimate) |
折射率 | 1.5430 (estimate) |
闪点 | >200°C |
储存条件 | Sealed in dry,2-8°C |
溶解度 | 溶于热乙酸中呈现微浑浊 |
酸度系数(pKa) | 6.27±0.20(Predicted) |
形态 | 粉末 |
颜色 | 橙棕色或棕色 |
水溶解性 | insoluble |
Merck | 14,2815 |
BRN | 2054727 |
LogP | 4.570 (est) |
CAS 数据库 | 117-10-2(CAS DataBase Reference) |
(IARC)致癌物分类 | 2B (Vol. 50) 1990 |
NIST化学物质信息 | 1,8-Dihydroxyanthraquinone(117-10-2) |
EPA化学物质信息 | Danthron (117-10-2) |
1,8-二羟基蒽醌 用途与合成方法
AMPK
|
Danthron (0.1, 1, and 10 μM) dose-dependently promotes the phosphorylation of AMPK and acetyl-CoA carboxylase (ACC) in both HepG2 and C2C12 cells. Meanwhile, Danthron treatment significantly reduces the lipid synthesis related sterol regulatory element-binding protein 1c (SREBP1c) and fatty acid synthetase (FAS) gene expressions, and the total cholesterol (TC) and triglyceride (TG) levels. In addition, Danthron treatment efficiently increases glucose consumption. Danthron effectively reduces intracellular lipid contents and enhances glucose consumption in vitro via activation of AMPK signaling pathway. 10 μM Danthron/24 h is safe for HepG2 cells. With 80% confluence, HepG2 cells are incubated with Danthron (0.1-10 μM) in FBS-Free media for 8 h. Subsequently, cells are harvested for Western blot assay. Danthron increases the p-AMPK protein in a dose-dependent manner, and no changes in t-AMPK protein are observed. Danthron inhibits 9-cis retinoic acid (9cRA)-induced retinoic X receptor α (RXRα) transactivation by IC 50 at 0.11 μM. To further clarify the stoichimetric ratio of Danthron binding to RXRα-ligand-binding domain (LBD), isothermal titration calorimetry (ITC) experiment is performed. The K D value of Danthron binds to RXRα-LBD by ITC experiment is determined at 7.5 μM.
Danthron functions as an insulin sensitizer in vivo. Danthron improves insulin sensitivity in diet-induced obese (DIO) mice. The insulin tolerance test result shows that Danthron (5 mg/kg) treated diet-induced obesity mice exhibit lower glucose levels after insulin challenge, compared with the control vehicle-treated group.
安全信息
危险品标志 | Xn |
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危险类别码 | 40 |
安全说明 | 36/37-36-22 |
危险品运输编号 | 2811 |
WGK Germany | 1 |
RTECS号 | CB6650000 |
TSCA | Yes |
危险等级 | IRRITANT |
海关编码 | 29146990 |
毒害物质数据 | 117-10-2(Hazardous Substances Data) |
毒性 | LD50 orally in mice: <7 g/kg (Case) |
MSDS信息
1,8-二羟基蒽醌 价格(试剂级)
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024-11-08 | A12001 | 1,8-二羟基蒽醌, 95% | 117-10-2 | 100g | 601 |
2024-11-08 | A12001 | 1,8-二羟基蒽醌, 95% | 117-10-2 | 500g | 1478 |