117-10-2
基本信息
1,8-二羟基喹酮
1,8-二羟基-9,10-蒽二酮
丹蒽醌
1,8-蒽醌二酚
以斯替净
1,8-二羟基蒽醌/丹蒽醌
1,8-二羥蒽醌
金黃異茜素
1, 9-DIHYDROXYANTHRAQUINONE
ALTAN
ANTHRAPUROL
CHRYSAZIN
CHRYSAZINE
DANTHRON
DANTRON
ISTIZIN
ISTIZINE
LABOTEST-BB LT00455159
1,4,5,8-tetroxyantraquinone
1,8-dihydroxy-10-anthracenedione
1,8-Dihydroxy-9,10-anthracenedione
1,8-Dihydroxy-9,10-anthraquinone
1,8-Dihydroxyanthra-9,10-quinone
1,8-Dihydroxyanthrachinon
1,8-dihydroxy-anthraquinon
1,8-dihydroxyanthroquinone
9,10-Anthracenedione, 1,8-dihydroxy-
物理化学性质
外观性质 | 橙色针状结晶。溶于热冰乙酸,微溶于乙醚和氯仿,极微溶于氢氧化碱,几乎不溶于水和乙醇。有致癌可能性。熔点:193℃-197℃ |
外观性状 | 橙色针状结晶,溶于甲醇、乙醇、乙酸乙酯、乙醚、三氯甲烷,几乎不溶于水,来源于雷公藤,丹参。 |
熔点 | 191-193 °C(lit.) |
沸点 | 342.92°C (rough estimate) |
密度 | 1.3032 (rough estimate) |
折射率 | 1.5430 (estimate) |
闪点 | >200°C |
储存条件 | Sealed in dry,2-8°C |
溶解度 | 溶于热乙酸中呈现微浑浊 |
酸度系数(pKa) | 6.27±0.20(Predicted) |
形态 | 粉末 |
颜色 | 橙棕色或棕色 |
水溶解性 | insoluble |
Merck | 14,2815 |
BRN | 2054727 |
LogP | 4.570 (est) |
CAS 数据库 | 117-10-2(CAS DataBase Reference) |
(IARC)致癌物分类 | 2B (Vol. 50) 1990 |
NIST化学物质信息 | 1,8-Dihydroxyanthraquinone(117-10-2) |
EPA化学物质信息 | Danthron (117-10-2) |
安全数据
危险性符号(GHS) | GHS07,GHS08 |
警示词 | 警告 |
危险性描述 | H315-H319-H335-H351 |
防范说明 | P201-P302+P352-P305+P351+P338-P308+P313 |
危险品标志 | Xn |
危险类别码 | R40 |
安全说明 | S36/37 |
危险品运输编号 | 2811 |
WGK Germany | 1 |
RTECS号 | CB6650000 |
TSCA | Yes |
危险等级 | IRRITANT |
海关编码 | 29146990 |
毒害物质数据 | 117-10-2(Hazardous Substances Data) |
毒性 | LD50 orally in mice: <7 g/kg (Case) |
应用领域
上下游产品信息
图谱信息
1,8-二羟基蒽醌(117-10-2)质谱(MS)1,8-二羟基蒽醌(117-10-2)核磁图(1HNMR)1,8-二羟基蒽醌(117-10-2)核磁图(13CNMR)1,8-二羟基蒽醌(117-10-2)红外图谱(IR1)1,8-二羟基蒽醌(117-10-2)红外图谱(IR2)知名试剂公司产品信息
1,8-Dihydroxyanthraquinone, 90-95%(117-10-2) Acros Organics
Chrysazin,>98.0%(T)(117-10-2) TCI Shanghai
1,8-二羟基蒽醌价格(试剂级)
报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
2024/11/08 | A12001 | 1,8-二羟基蒽醌, 95%
1,8-Dihydroxyanthraquinone, 95% | 117-10-2 | 100g | 601元 |
2024/11/08 | A12001 | 1,8-二羟基蒽醌, 95%
1,8-Dihydroxyanthraquinone, 95% | 117-10-2 | 500g | 1478元 |
2024/11/08 | 11483 | 1,8-二羟基蒽醌(95%) 1,8-Dihydroxyanthraquinone, 95%, Thermo Scientific Chemicals | 117-10-2 | 5g | 420元 |
常见问题列表
AMPK
|
Danthron (0.1, 1, and 10 μM) dose-dependently promotes the phosphorylation of AMPK and acetyl-CoA carboxylase (ACC) in both HepG2 and C2C12 cells. Meanwhile, Danthron treatment significantly reduces the lipid synthesis related sterol regulatory element-binding protein 1c (SREBP1c) and fatty acid synthetase (FAS) gene expressions, and the total cholesterol (TC) and triglyceride (TG) levels. In addition, Danthron treatment efficiently increases glucose consumption. Danthron effectively reduces intracellular lipid contents and enhances glucose consumption in vitro via activation of AMPK signaling pathway. 10 μM Danthron/24 h is safe for HepG2 cells. With 80% confluence, HepG2 cells are incubated with Danthron (0.1-10 μM) in FBS-Free media for 8 h. Subsequently, cells are harvested for Western blot assay. Danthron increases the p-AMPK protein in a dose-dependent manner, and no changes in t-AMPK protein are observed. Danthron inhibits 9-cis retinoic acid (9cRA)-induced retinoic X receptor α (RXRα) transactivation by IC 50 at 0.11 μM. To further clarify the stoichimetric ratio of Danthron binding to RXRα-ligand-binding domain (LBD), isothermal titration calorimetry (ITC) experiment is performed. The K D value of Danthron binds to RXRα-LBD by ITC experiment is determined at 7.5 μM.
Danthron functions as an insulin sensitizer in vivo. Danthron improves insulin sensitivity in diet-induced obese (DIO) mice. The insulin tolerance test result shows that Danthron (5 mg/kg) treated diet-induced obesity mice exhibit lower glucose levels after insulin challenge, compared with the control vehicle-treated group.