盐酸阿柔比星
盐酸阿柔比星 用途与合成方法
20S proteasome.
Topoisomerase I and II.
Aclacinomycin A could efficiently enter living cells and emit fluorescence
in situ
. Aclacinomycin A (10 μM for 15 min) is sufficient for clear detection of fluorescence in most of the cultured cells. Aclacinomycin A treatment (10 μM Acla for 15 min) results in approximately 20% dead (or nearly dead) cells.
Aclacinomycin A (Aclarubicin) effectively induces incorporation of exon 7 into SMN2 transcripts from the endogenous gene in type I SMA fibroblasts as well as into transcripts from a SMN2 minigene in the motor neuron cell line NSC34 .
Aclacinomycin A is very well absorbed in mice, rats, and dogs after its oral administration. The oral LD
50
(76.5 mg/kg) is about twice the iv LD
50
(35.6 mg/kg) in mice
[4
.
Aclacinomycin A (0.75-6 mg/kg, ip daily) dose-dependently exhibits tumor growth in mice-based Leukemia P-388 model
[4
.
| Animal Model: | DBA/2, CDF 1 (BALB/c×DBA/2) mice with Leukemia P-388 [4 . |
| Dosage: | 0.75 mg/kg, 1.5 mg/kg, 3 mg/kg, 6 mg/kg. |
| Administration: | Intraperitoneal administration daily for 10 days starting 3 hr after transplantation. |
| Result: | Inhibited tumor growth. |
盐酸阿柔比星 化学药品说明书
盐酸阿柔比星 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2023-01-06 | HY-N2306A | 盐酸阿柔比星 | 75443-99-1 | 5mg | 2800 |
| 2023-01-06 | HY-N2306A | 盐酸阿柔比星 | 75443-99-1 | 10 mM * 1 mLin DMSO | 4479 |
