Shionone is an effective inhibitor of human neutrophil elastase which may be used as a treatment for inflammatory lung diseases including H1N1 and SARS virus infections.
White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Aster tataricus.
Shionone is an effective inhibitor of human neutrophil elastase which may be used as a treatment for inflammatory lung diseases including H1N1 and SARS virus infections.
ChEBI: A tetracyclic triterpenoid that is perhydrochrysene which is substituted by methyl groups at positions 1, 4bbeta, 6aalpha, 8beta, 10abeta and 12a positions, by a 4-methylpent-3-enyl group
t the 8alpha position, and with an oxo group at position 2.
Shionone (orally administration; 80 mg/kg; 3 days; once daily) shows the trend of enhancing sputum secreting, but has no effect on ammonia-induced cough and reduces xylene-induced ear edema[1].
| Animal Model: | ICR male mice[1] |
| Dosage: | 80 mg/kg |
| Administration: | Orally administration; 3 days; once daily |
| Result: | Reduced the ear edema for 11.3% by use shionone. |
