ChemicalBook > Product Catalog > Flavors and fragrances > Synthetic fragrances > Aldehydes spices > Terpene aldehyde > Citronellal
Citronellal Chemical Properties
- Melting point:-16°C (estimate)
- alpha D25 +11.50°
- Boiling point:207 °C(lit.)
- Density 0.857 g/mL at 25 °C(lit.)
- vapor pressure 14 hPa (88 °C)
- refractive index n
- FEMA 2307 | CITRONELLAL
- Flash point:169 °F
- storage temp. 2-8°C
- form Liquid
- color Clear light yellow
- Specific Gravity0.858 (20/4℃)
- PH7 (H2O)
- explosive limit1.2-4.5%(V)
- Water Solubility Slightly miscible with water and ethanol.
- Sensitive Air Sensitive
- JECFA Number1220
- Merck 14,2329
- BRN 1720789
- CAS DataBase Reference106-23-0(CAS DataBase Reference)
- NIST Chemistry Reference6-Octenal, 3,7-dimethyl-(106-23-0)
- EPA Substance Registry SystemCitronellal (106-23-0)
- Hazard Codes Xn,Xi,N
- Risk Statements 38-43-51/53-36/37/38-22
- Safety Statements 36/37-61-37/39-26-36
- RIDADR UN 3082 9/PG 3
- WGK Germany 3
- RTECS RH2140000
- F 8
- Autoignition Temperature202 °C
- TSCA Yes
- HS Code 29121900
- Hazardous Substances Data106-23-0(Hazardous Substances Data)
- ToxicityLD50 orally in Rabbit: 2420 mg/kg LD50 dermal Rabbit > 2500 mg/kg
Citronellal Usage And Synthesis
- Chemical Propertiesclear light yellow liquid
- Chemical PropertiesCeylon citronella (C. nardus) and Java citronella (C. winterianus) are both perennial grasses growing more than 1 m high. The herb is harvested two to three times a year in Ceylon. The freshly cut or partially dried herb is steam distilled. The plant yields the largest amount of essential oil at about its third year of growth. Citronella is also cultivated and distilled in Java, Guatemala, Taiwan, Hainan, Argentina and New Guinea. The Java-type essential oil is considered to be of superior quality over the Ceylon type. Citronella has a characteristic citronella, rose- and lemon-like odor. The Council of Europe (CoE, 2000) has described Ceylon citronella and Java Citronella separately.
- Chemical PropertiesCitronellal has an intense, lemon-, citronella-, rose-type odor.
- Chemical Properties(?)-Citronellal occurs in Java citronella oil at a concentration of 35%. Racemic citronellal is the main constituent of E. citriodora
oil with a content of up to 85%.
Pure citronellal is a colorless liquid with a refreshing odor, reminiscent of lemon balm. Upon catalytic hydrogenation, citronellal yields dihydrocitronellal, citronellol, or dihydrocitronellol, depending on the reaction conditions. Protection of the aldehyde group, followed by addition of water to the double bond in the presence of mineral acids or ion-exchange resins results in the formation of 3,7-dimethyl-7-hydroxy-octan-l-al (hydroxydihydrocitronellal). Acid-catalyzed cyclization to isopulegol is an important step in the synthesis of (?)-menthol.
- OccurrenceThe d-form of citronellal has been reported in the oil of citronella (Ceylon, Jammus, Kaschmis), in the oil from leaves of Barosma pulchella, in the oil from roots of Phebalium nudum and in the oils of Eucalyptus citriodora, Leptospermum citratum and Baeckea citriodora. The /-form is present in the oils of Backhousia citriodora var. A, E. citriodora, Litsea cubeba (fruits) and lemongrass. Citronellal is generally present also in the oils of lemon, mandarin, Lavandula delphinensis, Ocimum canum f. citrata and many others (Fenarolis Handbook of Flavor Ingredients, 1971).
- Usesrac-Citronellal is a monoterpenoid and the major isolate in citronella oil. Citronella oil is an essential oil bearing insecticidal properties. rac-Citronellal is also often used as a fragrance ingred ient.
- Usescitronella is used primarily as a fragrance (perfuming and masking), it also has tonic properties. It is derived from the essential oil of the Cymbopogon nardus plant, and its constituents include geraniol (approximately 60 percent), citronellal, camphene, limonene, linalool, and borneol.
- UsesCitronellal is a flavoring agent that is a liquid, faintly yellow with an intense odor resembling lemon, citronella, and rose. it is soluble in alcohol and most fixed oils, slightly soluble in mineral oil and pro- pylene glycol, and insoluble in water and glycerin. it is obtained by chemical synthesis; the aldehyde may be obtained from natural oils, such as citronella oil. it is also termed 3,7-dimethyl-6-octen-1-a1.
- DefinitionChEBI: A monoterpenoid, the main component of citronella oil which gives it its distinctive lemon aroma.
- PreparationCitronellal is still isolated from essential oils in considerable quantities;
it is also produced synthetically.
1) Isolation from essential oils:(+)-Citronellal is obtained from citronella oils by fractional distillation. Racemic citronellal is isolated from E. citriodora oil; when necessary, it is purified by using an addition compound, for example, the bisulfite derivative.
2) Synthesis from geraniol or nerol: Racemic citronellal can be obtained by vaporphase rearrangement of geraniol or nerol in the presence of, for example, a barium-containing copper–chromium oxide catalyst.
3) Synthesis from citronellol: Racemic citronellal can also be obtained by dehydrogenation of citronellol under reduced pressure with a copper chromite catalyst.
4) Synthesis from citral: Selective hydrogenation of citral to citronellal can be accomplished in the presence of a palladium catalyst in an alkaline alcoholic reaction medium. A continuously operating process for the hydrogenation on a palladium catalyst in the presence of trimethylamine has been developed.
5) Synthesis from myrcene: (+)- and (?)-Citronellal are available from myrcene via geranyldiethylamine, which is enantioselectively isomerized to (+)- or (?)-citronellalenamine. Hydrolysis yields pure (+)- or (?)-citronellal; see monograph menthol.
- Essential oil compositionCitronella oil contains a number of fragrant fractions of which citronellal, geraniol and citronellol are the major components. Ceylon citronella oil contains 55 to 65% total acetylizable alcohols (calculated as citronellol) and 7 to 15% total aldehyde (calculated as citronellal). The main constituents are geraniol (18 to 20%), citronellol (6.4 to 8.4%), citronellal (5 to 15%), geranyl acetate (2%); limonene (9 to 11%) and methyl isoeugenol (7.2 to 11.3%). Other constituents are camphene, caryophyllene, linalool, citral (neral and geranial), methylheapenone, methyleugenol, l-borneol, nerol, eugenol and farnesol.* Java citronella oil contains not less than 35% alcohols (calculated as citronellol) and not less than 35% aldehydes (calculated as citronellal). The Java type appears to have higher concentrations of citronellol (35%) and geraniol (21%) than does the Ceylon type (citronellol 10% and geraniol 18%).
- Aroma threshold valuesDetection: 31 to 100 ppb
- Taste threshold valuesTaste characteristics at 10 ppm: floral, green, rosy and citrus-lemon.
- Synthesis Reference(s)Journal of the American Chemical Society, 108, p. 7314, 1986 DOI: 10.1021/ja00283a029
Tetrahedron Letters, 30, p. 5677, 1989 DOI: 10.1016/S0040-4039(00)76168-5
The Journal of Organic Chemistry, 49, p. 2279, 1984 DOI: 10.1021/jo00186a038
- Chemical SynthesisCan be prepared by chemical synthesis or by fractional distillation of natural oils, such as citronella. Industrially prepared by hydrogenation of β-citronellol or by catalytic hydrogenation of citral; also in the laboratory by dehydration of hydroxydihydrocitronellal.
- MetabolismFeeding 50 g citronellal to rabbits was followed by the isolation of 13 g of a crystalline glucuronide, which proved to be p-menthane-3.8-diol-D-glucuronide. The citronellal appeared to have been cyclized and the glucuronide obtained was identical with that obtained on feeding p-menthane-3,8-diol (menthoglycol) (Kühn & Low, 1938). However, evidence was produced to show that the cyclization was not, strictly speaking, a biological reaction, but a chemical one which took place in the stomach under the influence of the gastric hydrochloric acid. The conjugation of the menthoglycol with glucuronic acid was, of course, a purely biological reaction. It was found that on shaking 20 g citronellal with 200 ml 0-5% HCl for 48 hr at 37 C, 12 g menthoglycol was formed (Kühn & Low, 1938).
Citronellal Preparation Products And Raw materials
- Sodium prasterone sulfate 3beta-(methoxymethoxy)androst-5-en-17-one 20-OXO-20-DEOXYPHORBOL 12,13-DIBUTYRATE PHORBOL 12-MYRISTATE 13-ACETATE 5-METHYL-2-(1-METHYLETHYLIDENE)CYCLOHEXANONE PHORBOL, 20-OXO-20-DEOXY 12-MYRISTATE 13-ACETATE, 4BETA 4ALPHA-PHORBOL 4ALPHA-PHORBOL 12,13-DIDECANOATE PHORBOL-12-MONOMYRISTATE PHORBOL 12,13-DIACETATE CITRONELLIC ACID PHORBOL 12,13-DIBUTYRATE PHORBOL 12-MYRISTATE 13-ACETATE 4-O-METHYL ETHER, 4BETA Citronellal DMC ETHANE Dimethyl phthalate Dimethyl sulfate
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