Currently, there are many methods for preparing Ethyl difluoroacetate, including the following: Method 1, EP0694523 discloses a method for preparing Ethyl difluoroacetate. This method involves the addition of tetrafluoroethylene to methanol under catalysis to synthesize methoxytetrafluoroethane. The methoxytetrafluoroethane is then catalytically cracked to obtain difluoroacetyl fluoride, which is then esterified with ethanol to obtain Ethyl difluoroacetate.
Ethyl difluoroacetate is used in pharmaceutical intermediates, acrylization oxidation and halogenating reaction of catalyst. Also ethyl difluoroacetate is used in preparing pyrrazolo-pyrimidine derivatives.
