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Cloquintocet-mexyl

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Cloquintocet-mexyl Basic information
Cloquintocet-mexyl Chemical Properties
  • Melting point:69°
  • Boiling point:448.4±30.0 °C(Predicted)
  • Density 1.163±0.06 g/cm3(Predicted)
  • storage temp. Sealed in dry,2-8°C
  • form neat
  • pka1.94±0.29(Predicted)
  • Merck 14,2401
  • Stability:Stable. Incompatible with strong oxidizing agents.
  • CAS DataBase Reference99607-70-2(CAS DataBase Reference)
  • EPA Substance Registry SystemCloquintocet-mexyl (99607-70-2)
Safety Information
  • Hazard Codes Xi
  • Risk Statements 43
  • Safety Statements 36/37
  • RIDADR UN 3077
  • WGK Germany 2
  • RTECS AG1265000
  • ToxicityLD50 in rats (mg/kg): >2000 orally; >2000 dermally; LC50 (4 hr) in rats: >935 mg/m3 by inhalation (Amrein)
Cloquintocet-mexyl Usage And Synthesis
  • DescriptionCloquintocet-mexyl is a colourless crystalline herbicide safener. It is categorized as Class III toxin.
  • Chemical Propertiesbeige solid
  • UsesCloquintocet-mexyl is used as a herbicide.
  • UsesCloquintocet-mexyl is a herbicide. It is used to control coarse annual grass of the family poaceae (gramineae). lt was developed by the swiss ciba geigy in the 1980s and the patent has expired.
  • Agricultural UsesCloquintocet-mexyl is a safener that can be used in conjunction with various herbicides to reduce phytotoxicity to crops. Though effective as a safener, the manufacture, storage, and use of cloquintocet-mexyl containing products can present challenges owing to its sensitivity to water and its low melting temperature (i.e., 61-69° C. for technical material). When products containing cloquintocet-mexyl are prepared, stored, or used in the presence of water, cloquin tocet-mexyl can undergo hydrolysis to form cloquintocet acid, and/or form a needle-shaped, crystalline hydrate that can, lead to clogged spray nozzles during spray applications and/or possibly increased levels of crop phytotoxicity.
  • CarcinogenicityIn accordance with the EPA Proposed EPA Weight-of-the-Evidence Categories, August 1999, the HIARC classified cloquintocet-mexyl as "not likely to be a human carcinogen." Carcinogenicity studies in rats and mice did not show increased incidence of spontaneous tumor formation. With negative mutagenic test battery, it is suggested that cloquintocet-mexyl (CGA 185072) is not likely to be a human carcinogen.
  • MetabolismMetabolism studies in rats indicated that approximately 40% of the administered dose of cloquintocet-mexyl was absorbed through the gastrointestinal tract and subsequently excreted via the urine. Fecal excretion accounted for approximately 60% of the administered dose. The chemical was rapidly eliminated (more than 80% of the administered dose) via feces and urine within 48 hours post-dosing. Sex, dosing regime, and dose levels had little effect on the excretion pattern. Excretion patterns were similar between the biliary cannulated and non-cannulated animals indicating that there was no enterohepatic circulation of the chemical. Three days after administration, tissue radioactivity accounted for less than 0.3% of the administered dose (or was non-detectable) and was not detectable in the expired air. At day three post-dosing, most tissue residues of radioactivity were below the limit of detection. The major metabolic pathway of cloquintocet-mexyl was ester hydrolysis to yield 5-chloro-8-quinolinoxy acetic acid, the major metabolite in the fecal and urinary pools.
  • Toxicity evaluationCloquintocet-mexyl has a low order of acute oral, dermal, and inhalation toxicity. It is slightly irritating to the eyes and non-irritating to the skin. Cloquintocet-mexyl is a skin sensitizer. The chemical is not genotoxic and is not a reproductive and developmental toxicant. There is no evidence of neurotoxicity in the available studies. Cloquintocet-mexyl is classified as “not likely to be a human carcinogen.” The main metabolite for cloquintocet-mexyl is 5-chloro-8-quin-linoxyacetic acid, and testing on the metabolite is part of the toxicology database for cloquintocet-mexyl.
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