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4-Phenylpyridine

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4-Phenylpyridine Basic information
4-Phenylpyridine Chemical Properties
  • Melting point:69-73 °C (lit.)
  • Boiling point:274-275 °C (lit.)
  • Density 1.1088 (rough estimate)
  • refractive index 1.6210 (estimate)
  • storage temp. Inert atmosphere,Room Temperature
  • form Crystalline Powder
  • pka5.45±0.10(Predicted)
  • color Light yellow to beige
  • Water Solubility SOLUBLE
  • BRN 110490
  • CAS DataBase Reference939-23-1(CAS DataBase Reference)
  • NIST Chemistry Reference4-phenyl-pyridine(939-23-1)
  • EPA Substance Registry System4-Phenylpyridine (939-23-1)
Safety Information
  • Hazard Codes Xi
  • Risk Statements 36/37/38
  • Safety Statements 26-36
  • WGK Germany 3
  • RTECS UT7141000
  • 10
  • HazardClass IRRITANT, KEEP COLD
  • HS Code 29333990
MSDS
4-Phenylpyridine Usage And Synthesis
  • Chemical PropertiesLIGHT YELLOW TO BEIGE CRYSTALLINE POWDER
  • Uses4-Phenylpyridine is a useful synthetic intermediate. 4-Phenylpyridine has been shown to induce inhibition of mitochondrial respiration in mice.
  • Synthesis Reference(s)Journal of the American Chemical Society, 78, p. 1702, 1956 DOI: 10.1021/ja01589a060
    Synthetic Communications, 21, p. 619, 1991 DOI: 10.1080/00397919108020828
    Tetrahedron Letters, 36, p. 5247, 1995 DOI: 10.1016/0040-4039(95)00983-J
  • Enzyme inhibitor?This substituted pyridine (FW = 155.20 g/mol; CAS 939-23-1; M.P. = 69- 73°C; B.P. = 274-275°C), which occurs naturally and is likewise a manmade pollutant, inhibits human placental aromatase, Ki = 0.36 μM, monoamine oxidase, and NADH dehydrogenase. 4-Phenylpyridine is also an effective inhibitor of mitochondrial complex I. Note that it both occurs naturally and is an environmental pollutant.
4-Phenylpyridine Preparation Products And Raw materials
4-Phenylpyridine(939-23-1)Related Product Information
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