7-(Trifluoromethyl)indoline-2,3-dione is Brown Solid
An indole derivative as inhibitor of COX-1, COX-2, and β-catenin. Useful in the treatment of diseases such as: lung cancer, diabetes and Alzheimer''s disease.
7-(Trifluoromethyl)indoline-2,3-dione is an indole derivative as inhibitor of COX-1, COX-2, and catenin.Useful in the treatment of diseases such as: lung cancer, diabetes and Alzheimer disease.
General procedure: Concentrated sulfuric acid (95 mL) was preheated in a thermostatic flask at 60 °C. Intermediate 2 ((2E)-2-(hydroxyimino)-N-[2-(trifluoromethyl)phenyl]acetamide, 12 g, 52 mmol) was added slowly in batches while keeping the reaction temperature below 70 °C. Subsequently, the temperature of the reaction system was raised to 80°C for 3 hours. Upon completion of the reaction, the mixture was cooled to room temperature and quenched by slow pouring into crushed ice under vigorous stirring. The precipitated solid precipitate was collected by filtration and dried in a vacuum drying oven to give the final product 3 (7-(trifluoromethyl)dihydroindole-2,3-dione).
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[2] ACS Medicinal Chemistry Letters, 2013, vol. 4, # 1, p. 22 - 26
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