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Flunarizine dihydrochloride

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Flunarizine dihydrochloride Basic information
Flunarizine dihydrochloride Chemical Properties
  • Melting point:188-190?C
  • storage temp. 2-8°C
  • solubility chloroform/methanol (9:1): 50 mg/mL, clear, colorless
  • form neat
  • Merck 13,4170
  • BRN 4284243
  • CAS DataBase Reference30484-77-6(CAS DataBase Reference)
Safety Information
  • Hazard Codes Xn
  • Risk Statements 22
  • WGK Germany 3
  • RTECS TK9187000
MSDS
Flunarizine dihydrochloride Usage And Synthesis
  • Chemical PropertiesWhite Solid
  • OriginatorSibelium,Janssen,W. Germany,1977
  • Usesantipsychotic, H1 antihistamine
  • UsesCalcium channel blocker; fluorinated derivative of Cinnarizine. Vasodilator (cerebral and peripheral). This is the labeled analog.
  • Manufacturing ProcessA mixture of 14.3 parts of di-(p-fluorophenyl)-chloromethane, 10.1 parts of 1- cinnamylpiperazine, 12.7 parts of sodium carbonate, a few crystals of potassium iodide in 200 parts of 4-methyl-2-pentanone is stirred and refluxed for 21 hours. The reaction mixture is cooled and 50 parts of water are added. The organic layer is separated, dried, filtered and evaporated.
    The oily residue is dissolved in 480 parts of anhydrous diisopropyl ether. This solution is boiled with activated charcoal, filtered and to the clear filtrate is added an excess of 2-propanol, previously saturated with gaseous hydrogen chloride. The precipitated salt is filtered off and recrystallized from a mixture of 2-propanol and ethanol, yielding 1-cinnamyl-4-(di-p-fluorobenzhydryl) piperazine dihydrochloride, MP 251.5°C.
  • Therapeutic FunctionVasodilator
  • Biological ActivityDual Na + /Ca 2+ channel blocker; a cerebral and peripheral vasodilator. Neuroprotective.
Flunarizine dihydrochloride Preparation Products And Raw materials
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