托美丁钠(二水)
托美丁钠(二水) 性质
| 熔点 | 155-157 (dec.) |
|---|---|
| 储存条件 | -20°C Freezer |
| 溶解度 | 甲醇（微溶）、水（微溶） |
| 形态 | 固体 |
| 颜色 | 白色至米色 |
| 水溶解性 | Soluble in water |
| InChI | InChI=1S/C15H15NO3.Na.2H2O/c1-10-3-5-11(6-4-10)15(19)13-8-7-12(16(13)2)9-14(17)18;;;/h3-8H,9H2,1-2H3,(H,17,18);;2*1H2/q;+1;;/p-1 |
| InChIKey | QQILXENAYPUNEA-UHFFFAOYSA-M |
| SMILES | C1(=CC=C(CC([O-])=O)N1C)C(=O)C1C=CC(C)=CC=1.O.O.[Na+] |
| CAS 数据库 | 64490-92-2(CAS DataBase Reference) |
托美丁钠(二水) 用途与合成方法
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Human COX-1 0.35 μM (IC 50 ) |
Human COX-2 0.82 μM (IC 50 ) |
Tolmetin sodium dihydrate (0.25 mM) does not attenuate lipid peroxidation in rat brain homogenate. Tolmetin (0.25, 0.5, 0.75, 1 mM) shows radical scavenging properties but without superoxide anion generation in rat brain homogenat.
Tolmetin sodium dihydrate (0.001-100 μM) shows anticancer activity againts HT-29 colon cancer cell line in a dose-dependent manner.
Tolmetin sodium dihydrate (0-100 μM) shows no effect on osteoblast growth.
Tolmetin sodium dihydrate (30,100 mg/kg; gavage; single dose or twice daily for 3 and 14 days) shows maximal ulcerogenic effect 4 h after the single dose, while potently decreases after 3 and 14 days of repeated administration in male Wistar rats weighing 180-200 g. Tolmetin causes gastric lesions in 100 mg/kg.
Tolmetin sodium dihydrate (5 mg/kg twice a day for 5 days) pre-treatment considerably attenuates quinolinic acid (QA)-induced neurotoxicity.
安全信息
| 危险品标志 | Xn |
|---|---|
| 危险类别码 | 22-38 |
| 安全说明 | 36 |
| WGK Germany | 3 |
| RTECS号 | UX9280000 |
| 海关编码 | 2933995500 |
| 存储类别 | 11 - 可燃固体 |
| 危险性类别 | 急性毒性 类别4 经口 生殖毒性 类别2 |
托美丁钠(二水) 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-03-03 | S4360 | 托美丁钠(二水) | 64490-92-2 | 25mg | 795.3 |
| 2025-12-22 | HY-B1489 | 托美丁钠(二水) | 64490-92-2 | 100mg | 500 |
