Historically, potassium fluoride has been used with solvents to perform the Halex reaction and Finger and Kruse established the use of polar aprotic solvents in the Halex reaction, with DMSO and DMF being used for the conversion of pentachloropyridine to pentafluoropyridine.
Pentafluoropyridine was used in the preparation of η2-C,C coordinated pentafluoropyridine complex. It was also used in the preparation of polyfluorinated coupling products via Pd(0)-catalyzed cross-coupling reaction with diarylzinc compounds. It was also used as derivatizing reagent in the sensitive GC-MS method for determination of the four endocrine disrupting chemicals.
The reactions of pentafluoropyridine with cobalt(0) complex, Co(PMe3)4 was investigated.
Distil it through a concentric tube column; it has in cyclohexane at 256.8nm. [Chambers et al. J Chem Soc 3573 1964, NMR: Bell et al. J Fluorine Chem 1 51 1971.] The hexafluoroantimonate has m 98-102o(dec) after crystallisation from liquid SO2. [Beilstein 20/5 V 401.]
