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4-Nitrobenzoyl chloride

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4-Nitrobenzoyl chloride Basic information
4-Nitrobenzoyl chloride Chemical Properties
  • Melting point:71-74 °C(lit.)
  • Boiling point:202-205 °C105 mm Hg(lit.)
  • Density 1.53
  • refractive index 1.5890 (estimate)
  • Flash point:102 °C
  • storage temp. Store below +30°C.
  • solubility Soluble in terahydrofuran, dichloromethane, chloroform and pyridine.
  • form Flakes or Crystals
  • color Yellow
  • Water Solubility Decomposes
  • Sensitive Moisture Sensitive
  • Merck 14,6589
  • BRN 473192
  • Stability:Stability Stable, but moisture sensitive. Combustible. Incompatible with water, alcohols, strong oxidizing agents, strong bases.
  • InChIKeySKDHHIUENRGTHK-UHFFFAOYSA-N
  • CAS DataBase Reference122-04-3(CAS DataBase Reference)
  • NIST Chemistry Reference4-Nitrobenzoic acid chloride(122-04-3)
  • EPA Substance Registry Systemp-Nitrobenzoyl chloride (122-04-3)
Safety Information
  • Hazard Codes C
  • Risk Statements 34
  • Safety Statements 26-36/37/39-45
  • RIDADR UN 3261 8/PG 2
  • WGK Germany 2
  • RTECS DM6651000
  • 9-19-21
  • TSCA Yes
  • HazardClass 8
  • PackingGroup II
  • HS Code 29163900
  • ToxicityLD50 orally in Rabbit: 5600 mg/kg
MSDS
4-Nitrobenzoyl chloride Usage And Synthesis
  • Chemical Propertiesyellow needles or powder
  • Uses4-Nitrobenzoyl Chloride is used inorganic syntheses such as Michael additions. Also used in the synthesis of polysubstituted furanonaphthoquinoines.
  • General DescriptionYellow needles or powder with a pungent odor.
  • Air & Water ReactionsUnstable in moist surroundings and should be kept in a tightly-closed container. React with water or steam .
  • Reactivity Profile4-Nitrobenzoyl chloride is incompatible with bases (including amines), with strong oxidizing agents, and with alcohols. May react with reducing agents. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].
  • Health HazardTOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
  • Fire HazardFlash point data are not available for 4-Nitrobenzoyl chloride, but 4-Nitrobenzoyl chloride is combustible.
  • Safety ProfileModerately toxic by ingestion. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx and Cl-. See also NITRO COhlPOUNDS OF AROMATIC HYDROCARBONS and CHLORIDES.
  • Purification MethodsCrystallise the acid chloride from dry pet ether (b 60-80o), *C6H6 or CCl4. Distil it under vacuum. Irritant. [Adama & Jenkins Org Synth Coll Vol I 394 1941, Beilstein 9 III 1709, 9 IV 1191.]
4-Nitrobenzoyl chloride Preparation Products And Raw materials
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