Procyanidin B3 (100 mg/kg, p.o., 5 days a week for 4 weeks) prevents articular cartilage degeneration and heterotopic cartilage formation in a surgically-induced osteoarthritis mice model[2].
Procyanidin B3 (30 mg/kg, p.o., once daily for 4 weeks) delays the development of intervertebral disc degeneration (IVDD) in a Lipopolysaccharides (HY-D1056)-induced IVDD Sprague-Dawley rats model[2].
| Animal Model: | Lipopolysaccharides (HY-D1056)-induced IVDD (intervertebral disc degeneration) Sprague-Dawley rats model |
| Dosage: | 30 mg/kg |
| Administration: | Oral gavage (p.o.),once daily for 4 weeks |
| Result: | Prevented the loss of gelatin NP cells and structural damage of annulus fibrosus in IVDD rat model. |
| Animal Model: | Surgically-induced osteoarthritis mice model[2] |
| Dosage: | 100 mg/kg |
| Administration: | Oral gavage (p.o.), once daily, 5 days a week for 4 weeks |
| Result: | Prevented aberrant articular cartilage degeneration and heterotopic cartilage formation through suppression of the nitric oxide synthase (iNOS). |
