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Benidipine

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Benidipine Basic information
Benidipine Chemical Properties
  • Boiling point:625.2±55.0 °C(Predicted)
  • Density 1.29±0.1 g/cm3(Predicted)
  • pkapKa 7.34(H2O(long extrapolation) ) (Uncertain)
  • CAS DataBase Reference105979-17-7(CAS DataBase Reference)
Benidipine Usage And Synthesis
  • Enzyme inhibitorThis oral, once-daily antihypertensive agent (FW = 505.57 g/mol; CAS 105979-17-7), also known by its code name KW-3049, trade name Coniel?, and systematic name O -methyl,O -[(3R)-1-(phenylmethyl)piperidin-3-yl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, is a dihydropyridine-class calcium ion blocker that is effective against L-, N-, and T-channels, with potent and selective inhibitory action on cardiac slow calcium channels. Benidipine bound stereospecifically to nitrendipine binding sites of rat myocardium with high affinity (Ki = 0.13 nM) and to the rat brain a1-adrenergic receptor (Ki = 1.2 μM). KW-3049 exhibited no remarkable binding affinity to a2 adrenergic, b-adrenergic, D2 dopamine, H1 histamine, S2 serotonin, A1 adenosine, A2 adenosine and muscarinic cholinergic receptors at 100 μM.
Benidipine Preparation Products And Raw materials
Benidipine(105979-17-7)Related Product Information
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