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Nitrendipine

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Nitrendipine Basic information
Nitrendipine Chemical Properties
  • Melting point:1580C
  • Boiling point:492.4°C (rough estimate)
  • Density 1.3595 (rough estimate)
  • refractive index 1.5700 (estimate)
  • storage temp. Store at RT
  • solubility methanol: 15 mg/mL
  • form powder
  • pka2.79±0.70(Predicted)
  • color yellow to green
  • Water Solubility Soluble in DMSO (17.5 mg/ml), methanol (15 mg/ml), ethyl acetate, and ethanol (25 mM). Insoluble in water.
  • CAS DataBase Reference39562-70-4(CAS DataBase Reference)
  • NIST Chemistry ReferenceNitrendipine(39562-70-4)
Safety Information
  • Hazard Codes Xn
  • Risk Statements 20/21/22
  • Safety Statements 36
  • WGK Germany 1
  • RTECS US5653000
  • ToxicityLD50 in mice, rats (mg/kg): 39, 12.6 i.v.; 2540, >10000 orally (Hoffmann)
MSDS
Nitrendipine Usage And Synthesis
  • DescriptionNitrendipine is a vasodilating, dihydropyridine calcium antagonist. Its prolonged therapeutic effect in comparison to nifedipine makes it useful in the once to twice daily treatment of hypertension.
  • Chemical PropertiesCrystalline Solid
  • OriginatorBayer (W. Germany)
  • UsesAntihypertensive;Calcium channel blocker
  • UsesNitrendipine is a dihydropyridine calcium channel blocker. Nitrendipine is used in the treatment of primary (essential) hypertension to decrease blood pressure. Antihypertensive.
  • DefinitionChEBI: A dihydropyridine that is 1,4-dihydropyridine substituted by methyl groups at positions 2 and 6, a 3-nitrophenyl group at position 4, a ethoxycarbonyl group at position 3 and a methoxycarbonyl group at position 5. It is a calcium-channel blocker used in t e treatment of hypertension.
  • brand nameBaypress (Bayer);BAYOTENSIN.
  • General DescriptionNitrendipine, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinecarboxylic acid methyl ethylester (Baypress), is a second-generation dihydropyridinechannel blocker of the nifedipine type. It is more selectivefor vascular smooth muscle than for myocardial tissue andserves as an effective vasodilator. The drug is used in thetreatment of mild-to-moderate essential hypertension.
  • Biological ActivityL-type calcium channel blocker.
Nitrendipine Preparation Products And Raw materials
Nitrendipine(39562-70-4)Related Product Information
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