Nitrendipine is a vasodilating, dihydropyridine calcium antagonist. Its prolonged
therapeutic effect in comparison to nifedipine makes it useful in the once to twice
daily treatment of hypertension.
Antihypertensive;Calcium channel blocker
Nitrendipine modulates NMDA receptor channel function in mammalian neurons. Nitrendipine has been shown to inhibit neutrophil adhesion to vascular endothelium. It is used in the treatment of primary hypertension to decrease blood pressure. Nitrendipine is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina.
Nitrendipine is a dihydropyridine calcium channel blocker. Nitrendipine is used in the treatment of primary (essential) hypertension to decrease blood pressure. Antihypertensive.
ChEBI: A dihydropyridine that is 1,4-dihydropyridine substituted by methyl groups at positions 2 and 6, a 3-nitrophenyl group at position 4, a ethoxycarbonyl group at position 3 and a methoxycarbonyl group at position 5. It is a calcium-channel blocker used in t
e treatment of hypertension.
Baypress (Bayer);BAYOTENSIN.
Nitrendipine, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinecarboxylic acid methyl ethylester (Baypress), is a second-generation dihydropyridinechannel blocker of the nifedipine type. It is more selectivefor vascular smooth muscle than for myocardial tissue andserves as an effective vasodilator. The drug is used in thetreatment of mild-to-moderate essential hypertension.
L-type calcium channel blocker.
Ca2+ channel blocker; anti-hypertensive.
[1] H. MEYER. ChemInform Abstract: SYNTHESIS AND COMPARATIVE PHARMACOLOGICAL STUDIES OF 1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)PYRIDINE-3,5-DICARBOXYLATES WITH NON-IDENTICAL ESTER FUNCTIONS[J]. ChemInform, 1981, 12 27. DOI:
10.1002/chin.198127214[2] K STOEPEL S K A Heise. Pharmacological studies of the antihypertensive effect of nitrendipine.[J]. Arzneimittel-Forschung-Drug Research, 1981, 31 12: 2056-2061.
