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3-HYDROXY-3-METHYLGLUTARIC ACID

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3-HYDROXY-3-METHYLGLUTARIC ACID Basic information
3-HYDROXY-3-METHYLGLUTARIC ACID Chemical Properties
  • Melting point:105-108 °C (lit.)
  • Boiling point:120 °C / 13mmHg
  • Density 1.2132 (rough estimate)
  • refractive index 1.4230 (estimate)
  • storage temp. -20°C
  • pka3.95±0.10(Predicted)
  • Merck 14,5808
  • BRN 1769194
  • CAS DataBase Reference503-49-1(CAS DataBase Reference)
Safety Information
  • Hazard Codes Xi
  • Risk Statements 36/37/38
  • Safety Statements 22-24/25-36-26
  • WGK Germany 2
  • RTECS MA3753000
  • 10
  • HS Code 29181990
  • ToxicityLD50 in mice (g/kg): 7.33 orally; 3.23 i.p. (Savoie, Lupien)
MSDS
3-HYDROXY-3-METHYLGLUTARIC ACID Usage And Synthesis
  • DescriptionMeglutol (β-hydroxy-β-methylglutaric acid; HMG) is a hypolipidemic agent that acts via the inhibition of cholesterol synthesis a t the stage of HMG-CoAreductase, blocking the conversion of HMG-CoA to mevalonate. This conversion is the rate-limiting step in cholesterol biosynthesis and is the point of physiological feedback control; as such, it appears to be the ideal locus of action for a hypolipidemic agent. Investigational compounds that act by this mechanism include the natural products compactin and mevinolin.
  • Chemical PropertiesWhite Solid
  • OriginatorAligarh Muslim Univ. (India)
  • Usesantihyperlipoproteinemia
  • DefinitionChEBI: A dicarboxylic acid that is glutaric acid in which one of the two hydrogens at position 3 is substituted by a hydroxy group, while the other is substituted by a methyl group. It has been found to accumulate in urine of patients suffering from HMG-CoA lyase (3-hydroxy-3-methylglutaryl-CoA lyase, EC 4.1.3.4) deficiency. It occurs as a plant metabolite in Crotalaria dura.
  • brand nameLIPOGLUTAREN
  • Synthesis Reference(s)Synthesis, p. 791, 1981 DOI: 10.1055/s-1981-29596
  • Purification MethodsRecrystallise the acid from diethyl ether/hexane and dry it under avacuum at 60o for 1hour. [Beilstein 3 IV 1166.]
3-HYDROXY-3-METHYLGLUTARIC ACID Preparation Products And Raw materials
3-HYDROXY-3-METHYLGLUTARIC ACID(503-49-1)Related Product Information
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