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Torasemide

Basic information Diuretics Uses Safety Related Supplier
Torasemide Basic information
Torasemide Chemical Properties
Safety Information
  • Hazard Codes Xi
  • Risk Statements 36-36/37/38
  • Safety Statements 26-37/39
  • WGK Germany 2
  • RTECS UT7938000
  • HS Code 2935904000
MSDS
Torasemide Usage And Synthesis
  • DiureticsDiuretics are drugs mainly acting on the kidneys to increase the excretion of water and electrolytes, and increase urine output. Their potency can be divided into:
    1. potent diuretics (loop diuretics): including furosemide, bumetanide, ethacrynic acid.
    2. Middle efficiency diuretics include: thiazide diuretics, such as hydrochlorothiazide, bendroflumethiazide and so on.
    3. Inefficient diuretics include: retention of potassium diuretics spironolactone, triamterene and carbonic anhydrase inhibitor acetazolamide and the like.
    Potent diuretics effect on medullary loop ramus crude segment medulla,they inhibit reabsorption of active chlorine, followed by inhibiting sodium reabsorption, and play a strong diuretic effect.
    Torasemide is a potent diuretic, its mechanism of action is similar to furosemide, it has no effect on the proximal tubules, it does not cause an increase in the discharge of potassium. This product increase renal volume and sodium excretion is dose-dependent , it does not affect the calcium and potassium excretion, excretion and metabolism have no association with renal function, large doses have no significant toxicity. Sort diuretic strength by: bumetanide> torasemide> piretanide> furosemide. It is useful in the treatment of acute and chronic renal failure and essential hypertension. Adverse reactions of torasemide are similar to furosemide ,common adverse reactions are headache, dizziness, weakness, nausea, muscle spasms, but it produces lesser extent of potassium loss ,it has no effect on uric acid, blood glucose and lipid .
    The above information is edited by the chemicalbook of Tian Ye.
  • UsesIt is used as a diuretic.
  • DescriptionTorasemide is a novel loop diuretic launched in 1993 after a 12-year gap from the last diuretic introduction. It is indicated for the treatment of hypertension and edema associated with chronic congestive heart failure, renal disease and hepatic cirrhosis. Torasemide exerts its major diuretic activity on the thick ascending limb of the Henle's loop to promote rapid and marked excretion of water, Na+, Cl-, and to a lesser extent,K+ and Ca2+. Compared with other loop diuretics such as furosemide, torasemide has a stronger antihypertensive action, a higher bioavailability, a longer duration of action that is independent of the renal function, and has no side effects such as paradoxical antidiuresis. The mechanism of its vasodilating effect has been suggested to result from, at least in part, the competitive antagonism of the thromboxane A2 receptor.
  • Chemical PropertiesCrystalline Solid
  • OriginatorHafslund Nycomed Germany; Italy (Norway)
  • Usesalcohol dehydrogenase inhibitor, antidote
  • UsesUsed as a diuretic
  • DefinitionChEBI: An N-sulfonylurea obtained by formal condensation of [(3-methylphenyl)amino]pyridine-3-sulfonic acid with the free amino group of N-isopropylurea.
  • brand nameTorasemide is INN and BAN;Unat;Toradiur.
Torasemide(56211-40-6)Related Product Information
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