Isoastilbin

Isoastilbin (IA) is a dihydroflavonol glycoside compound, and studies have shown that IA has a good effect on antioxidants.

Isoastilbin is a dihydroflavonol glycoside compound in Rhizoma Smilacis glabrae and Astragalus membranaceus. Isoastilbin inhibits glucosyltransferase (GTase) with an IC50 value of 54.3 μg/mL, and also inhibits tyrosinase activity. Isoastilbin shows neuroprotective, antioxidation, antimicrobial and anti-apoptotic properties and has the potential for Alzheimer’s disease research[1][21][3].

Isoastilbin, a dihydroflavonol glycoside compound in Rhizoma Smilacis glabrae and Astragalus membranaceus. It inhibits glucosyltransferase (GTase) with IC50 value of 54.3 μg/mL, and also inhibits tyrosinase activity. It has neuroprotective, antioxidant, antimicrobial and anti-apoptotic properties and can be used in Alzheimer's disease research.

[1] Hong Yu, et al. Protective Roles of Isoastilbin Against Alz heimer's Disease via Nrf2-mediated Antioxidation and antiapoptosis. Int J Mol Med. 2019 Mar;43(3):1406-1416. DOI:10.3892/ijmm.2019.4058
[2] Harlinda Kuspradini, et al. Antimicrobial activity against Streptococcus sobrinus and glucosyltransferase inhibitory activity of taxifolin and some flavanonol rhamnosides from kempas (Koompassia malaccensis) extracts. J. Wood Sci., 2009, 55(4):308-13.
[3] Batubara, Irmanida, et al. Anti-acne and Tyrosinase Inhibition Properties of Taxifolin and Some Flavanonol Rhamnosides from Kempas. Wood Research Journal ,2010, 1(1):45-9.