| 名称 | Isoastilbin |
| 描述 | Isoastilbin is a dihydroflavonol glycoside compound found in Rhizoma Smilacis glabrae and Astragalus membranaceus. Isoastilbin inhibits glucosyltransferase (GTase) with an IC50 value of 54.3 μg/mL and possesses anti-acne and tyrosinase inhibition properties. Additionally, isoastilbin demonstrates neuroprotective, antioxidation, antimicrobial, and anti-apoptotic properties, indicating potential for Alzheimer's disease research. |
| 体外活性 | The crude extracts were assayed for antimicrobial activities against Streptococcus sobrinus and for glucosyltransferase (GTase) inhibition. Fourteen extracts inhibited the growth of S. sobrinus by more than 50% and six extracts inhibited GTase activity by more than 50% at a concentration of 100 μg/ml. Koompassia malaccensis (kempas) extracts showed 90% depression of S. sobrinus growth and 80% inhibition of GTase activity at a concentration of 100 μg/ml. Kempas crude extracts were subjected to column chromatography using Sephadex LH-20 and then preparative high-performance liquid chromatography to isolate four compounds A, B, C, and D. These compounds were identified as taxifolin and the flavanonol rhamnoside isomers neoastilbin, astilbin, and Isoastilbin, respectively, from 1H and 13C nuclear magnetic resonance (NMR) spectra and other two-dimensional NMR techniques (COSY, HMBC, and HMQC). Each compound depressed the growth of S. sobrinus over a concentration range of 9.3242.7 μg/ml and showed GTase inhibitory activity with IC50 values in the range 27.4-57.3 μg/ml[1] |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 25 mg/mL (55.51 mM)
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| 关键字 | disease | anti-apoptotic | glycoside | Tyrosinase | Bacterial | antimicrobial | Inhibitor | Antioxidation | inhibit | Isoastilbin | dihydroflavonol | neuroprotective | Alzheimer's |
| 相关产品 | Neomycin sulfate | Dehydroacetic acid sodium | Ampicillin sodium | Kojic acid | Methyl anthranilate | Kanamycin sulfate | Sulfamethoxazole sodium | Metronidazole | Doxycycline | Oxyresveratrol | Dimethyl sulfoxide | Crystal Violet |
| 相关库 | 黄酮类天然产物库 | 植物来源化合物库 | 天然产物库 | 苗药化合物库 | 抑制剂库 | 神经保护化合物库 | 抗感染天然产物库 | 抗衰老化合物库 | 已知活性化合物库 | 药食同源库 |
United States
