N,N,N',N'-Tetramethylfluoroformamidinium hexafluorophosphate is a useful reagent for in situ conversion of carboxylic acids to acid fluorides. Particularly useful for the coupling of sterically hindered amino acids.
Fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate is used as a reagent for synthesis of cationic antimicrobial β-2,2-amino acid derivatives, philanthotoxin analogues for inhibition of the ionotropic glutamate receptor, small β-peptidomimetics for antimicrobials and hydrazone ligation to assemble multifunctional viral nanoparticles.
