This alkaloid from Spiraea japonica L. fil. has been obtained as the crystalline
hydrochloride, m.p. l14-7°C. Chemical evidence has shown it to be acetyl_x0002_spiradine G. Oxidation with chromic acid in pyridine yields a hydroxy-Iactam in
which the hydroxyl and lactam groups are formed by oxidative cleavage of an
intermediate alkanolamine ether.
Spiradine F is a main alkaloidal component of spiraea japonioa L. fil. Spiradine F derivative can inhibit platelet-activating factor (PAF)-induced platelet aggregation[1][2].
Toda, Hirata., Tetrahedron Lett., 5565 (1968)
