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Thionicotinamide adenine dinucleotide

Product NameThionicotinamide adenine dinucleotide
CAS4090-29-3
MFC21H27N7O13P2S
MW679.49
EINECS223-828-6
MOL File4090-29-3.mol

Chemical Properties

storage temp.	-20°C
solubility	PBS (pH 7.2): 10 mg/ml
form	powder to crystal
color	Light orange to Yellow to Green
InChIKey	DQRRIGAXTAXHLR-NNYOXOHSSA-N
SMILES	O[C@@H]1[C@@H]([C@@H](COP(O)(=O)OP([O-])(=O)OC[C@@H]2[C@H]([C@@H](O)[C@H]([N+]3=CC=CC(C(=S)N)=C3)O2)O)O[C@H]1N1C=NC2C(=NC=NC1=2)N)O \|&1:1,2,3,15,16,17,19,32,r\|
CAS DataBase Reference	4090-29-3

Safety Information

Hazard Codes	Xn
Risk Statements	20/21/22-36/37/38
Safety Statements	26-36
WGK Germany	-
HS Code	29349990
Storage Class	11 - Combustible Solids

MSDS

Provider	Language
SigmaAldrich	English

Usage And Synthesis

Description

Thionicotinamide adenine dinucleotide is an analog of NAD. Use of Thio-NAD instead of NAD as a substrate for NAD(+)-consuming enzymes is more advantageous since the reduced form of Thio-NAD exhibits a substantial increase in absorbance at 405 nM, the most commonly available wavelength on microplate readers.

Chemical Properties

Light yellow powder

Uses

Thionicotinamide adenine dinucleotide has been used as a substrate analog in S-adenosyl-l-homocysteine (AdoHcy) hydrolases (SAHH) inhibition assay and in NAD+ glycohydrolase activity.

Application

Thionicotinamide adenine dinucleotide (thio-NAD) is a NAD derivative used in the determination of Carnitine by an enzymic cycling method with carnitine dehydrogenase.

Biochem/physiol Actions

Thionicotinamide adenine dinucleotide (sNAD) is an analog of coenzyme nicotinamide adenine dinucleotide (NAD) and NADH. sNAD is a potential inhibitor of NAD+ kinase. NAD+ kinase modulates NAD levels, contributing to cytotoxicity in cancer cells.

storage

Transport product sealed, dry, and protected from light at ambient temperature. Store product dry and protected from light. For long term storage keep below -20℃.

References

[1] SATOSHI WATABE. Ultrasensitive enzyme-linked immunosorbent assay (ELISA) of proteins by combination with the thio-NAD cycling method.[J]. Biophysics (Nagoya-shi, Japan), 2014, 10: 49-54. DOI: 10.2142/biophysics.10.49
[2] YUTA KYOSEI. Proposal of De Novo Antigen Test for COVID-19: Ultrasensitive Detection of Spike Proteins of SARS-CoV-2.[C]//10 8. 2020. DOI: 10.3390/diagnostics10080594
[3] WEN-HUNG WANG. A novel, rapid (within hours) culture-free diagnostic method for detecting live Mycobacterium tuberculosis with high sensitivity.[J]. EBioMedicine, 2020, 60: 103007. DOI: 10.1016/j.ebiom.2020.103007

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