N-Methylnicotinamide (3-30 mg/kg, i.v., 10 min before the induction of arterial thrombosis) decreases the arterial thrombus weight, collagen induced platelet aggregation and decreases PAI-1 antigen and activity in plasma without changing t-PA activity in 2K-1C hypertensive rats[1].
N-Methylnicotinamide (30-300 mg/kg, mixed in the diet, daily for 31 days) significantly increases the liver weight, the content of NAD and total nicotinamide in liver and the content of NAD in blood in rats[3].
| Animal Model: | 2K-1C hypertensive rats[1] |
| Dosage: | 3-30 mg/kg |
| Administration: | i.v., 10 min before the induction of arterial thrombosis |
| Result: | Resulted in a dose-dependent decrease of arterial thrombus weight, decreased PAI-1 antigen and activity in plasma in dose-dependent manner, whereas it did not change t-PA activity, decreased collagen induced platelet aggregation in dose-dependent manner. |
| Animal Model: | Weanling male rats[3] |
| Dosage: | 30-300 mg/kg |
| Administration: | mixed in the diet, daily for 31 days |
| Result: | Significantly increased the liver weight, statistically significantly the content of NAD and total nicotinamide in liver and the content of NAD in blood in rats. |
