5-Fluoro-2-methoxyaniline

445-83-0

1978-39-8

General procedure for the synthesis of 2-methoxy-5-fluoroaniline from 2-nitro-4-fluoroanisole: 4-fluoro-2-nitroanisole (85 g, 0.50 mol) was dissolved in methanol (300 mL) and palladium-carbon catalyst (10%, 8 g) was added. The reaction was stirred under hydrogen atmosphere for 15 hours. After completion of the reaction, the catalyst was removed by filtration, and the filtrate was concentrated to dryness to obtain the crude product 2-methoxy-5-fluoroaniline (61.5 g, 0.436 mol, 87% yield), which could be directly used in the next reaction without further purification.