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Basic information Description References Safety Related Supplier
Propanil Basic information
Propanil Chemical Properties
  • Melting point:92-93°C
  • Boiling point:369.9±32.0 °C(Predicted)
  • Density 1.25
  • refractive index 1.5680 (estimate)
  • Flash point:100 °C
  • storage temp.  0-6°C
  • form Solid
  • pka13.58±0.70(Predicted)
  • color Dark brown, blue-black
  • Water Solubility 225mg/L(room temperature)
  • Merck 13,7896
  • BRN 2365645
  • CAS DataBase Reference709-98-8
  • NIST Chemistry ReferencePropanil(709-98-8)
  • EPA Substance Registry SystemPropanil (709-98-8)
Safety Information
  • Hazard Codes Xn;N,N,Xn
  • Risk Statements 22-50
  • Safety Statements 2-22-61
  • RIDADR UN 3077 9/PG 3
  • WGK Germany 3
  • RTECS UE4900000
  • HazardClass 9
  • PackingGroup III
  • HS Code 29242990
  • Hazardous Substances Data709-98-8(Hazardous Substances Data)
  • ToxicityLD50 orally in rats: 1384 mg/kg (Bailey, White)
Propanil Usage And Synthesis
  • DescriptionPropanil (3,4-dichloropropionanilide) is an acetanilide post-emergency herbicide with no residual effect. It can be prepared by reaction of 3,4-dichloroaniline with propionic acid in the presence of thionyl chloride. Propanil is in toxicity class II - moderately toxic, due to its potential to irritate eyes and skin.
    Propanil functionalizes by the inhibition of RNA/protein synthesis and the inhibition of anthocyanin. Propanil is used to against numerous grasses and broad-leaved weeds in rice (mainly), potatoes, and wheat. It is typically applied aerially.
  • References[1] S. M. Richards, G. Y. H. McClure, T. L. Lavy, J. D. Mattice, R. J. Keller, J. Gandy (2001) Propanil (3,4-Dichloropropionanilide) Particulate Concentrations Within and Near the Residences of Families Living Adjacent to Aerially Sprayed Rice Fields, Arch. Environ. Contam. Toxicol. 41, 112–116
    [2] Michael A. Kamrin (1997) Pesticide Profiles: Toxicity, Environmental Impact, and Fate
  • Descriptionpropanil is used as a rice herbicide. The resistance of rice plants toward propanil has been found in an enzyme aryl-acylamidase that rapidly hydrolyzes the herbicide. This enzyme can be inhibited by carbamate insecticides, and this can lead to an increased propanil phytotoxicity (38).
  • Chemical PropertiesPropanil is a colorless solid. The technical product is a brown crystalline solid.
  • Chemical Properties(Pure) Light-brown solid.
  • UsesPropanil is a a widely used herbicide. Propanil is used mainly to control weed growth in rice fields.
  • Uses Postemergence herbicide, especially for rice culture; nematocide.
  • UsesSelective preemergence and postemergence herbicide used to control many grasses and broad-leaved weeds in potatoes, rice and wheat.
  • General DescriptionColorless to brown crystals. Non corrosive. Used as an herbicide.
  • Air & Water ReactionsHydrolyzed by acid and alkaline media.
  • Reactivity ProfilePropanil is incompatible with carbamates and organophosphates.
  • HazardToxic by ingestion and inhalation.
  • Agricultural UsesHerbicide: Propanil is a post-emergence herbicide with no residual effect. It is used against numerous grasses and broadleaved weeds in rice, potatoes, and wheat. Mixing with carbamates or organophosphorus compounds is not recommended. It is also used on wheat in a mixture with MCPA. With carbaryl, it is used in citrus crops grown in sod culture. Not approved for use in EU countries (re-submitted). Registered for use in the U.S.
  • Trade nameCekupropanil; DCPA; N-(3,4-Dichlorophenyl) propanamide; 3',4'-Dichlorophenyl propionanilide; 3,4-Dichloropropionanilide; 3',4'-Dichloropropionanilide; Dichloropropionanilide; Dipram; DPA; NSC 31312; Propanamide, N-(3,4-Dichlorophenyl)-; Propanide; Propionanilide, 3',4'-Dichloro-; Propionic acid, 3,4-dichloroanilide
  • Safety ProfilePoison by ingestion. Moderately toxic by an unspecified route. Mildly toxic by skin contact. Mutation data reported. When heated to decomposition it emits very toxic fumes of Cl and NOx.
  • Potential ExposurePropanil is used as a postemergent herbicide for rice and spring wheat. A potential danger to those involved in the manufacture, formulation, and application of this contact herbicide.
  • Environmental FateBiological. In the presence of suspended natural populations from unpolluted aquatic systems, the second-order microbial transformation rate constant determined in the laboratory was reported to be 5 × 10–10 L/organisms-hour (Steen, 1991).
    Soil. Propanil degrades in soil forming 3,4-dichloroaniline (Bartha, 1968; Bartha and Pramer, 1970; Chisaka and Kearney, 1970; Bartha, 1971; Duke et al., 1991; Pothuluri et al., 1991) which is further degraded by microbial peroxidases to 3,3′,4,4′-tetrachloroazobenzene (Bartha and Pramer, 1967; Bartha et al., 1968; Chisaka and Kearney, 1970), 3,3′,4,4′-tetrachloroazooxybenzene (Bartha and Pramer, 1970), 4-(3,4-dichloroanilo)- 3,3′,4,4′-tetrachloroazobenzene (Linke and Bartha, 1970) and 1,3-bis(3,4-dichlorophenyl)triazine (Plimmer et al., 1970a), propanoic acid, carbon dioxide and unidentified products (Chisaka and Kearney, 1970). Evidence suggests that 3,3′,4,4′-tetrachloroazobenzene reacted with 3,4-dichloroaniline forming a new reaction product, namely 4-(3,4- dichloroanilo)-3,3′,4′-trichloroazobenzene (Chisaka and Kearney, 1970). Under aerobic conditions, propanil in a biologically active, organic-rich pond sediment underwent dechlorination at the para- position forming N-(3-chlorophenyl)propanamide (Stepp et al., 1985). Residual activity in soil is limited to approximately 3–4 months (Hartley and Kidd, 1987).
    Plant. In rice plants, propanil is rapidly hydrolyzed via an aryl acylamidase enzyme isolated by Frear and Still (1968) forming the nonphototoxic compounds (Ashton and Monaco, 1991) 3,4-dichloroaniline, propionic acid (Matsunaka, 1969; Menn and Still, 1977; Hatzios, 1991) and a 3′,4′-dichloroaniline-lignin complex. This complex was identified as a metabolite of N-(3,4-dichlorophenyl)glucosylamine, a 3,4-dichloroaniline saccharide conjugate and a 3,4-dichloroaniline sugar derivative (Yi et al., 1968). In a rice field soil under anaerobic conditions, however, propanil underwent amide hydrolysis and dechlorination at the para position forming 3,4-dichloroaniline and m-chloroaniline (Pettigrew et al., 1985). In addition, propanil may degrade indirectly via an initial oxidation step resulting in the formation of 3,4-dichlorolacetanilide which is further hydrolyzed to 3,4-dichloroaniline and lactic acid (Hatzios, 1991). In an earlier study, four metabolites were identified in rice plants, two of which were positively identified as 3,4-dichloroaniline and N-(3,4-dichlorophenyl)glucosylamine (Still, 1968).
    Photolytic. Photoproducts reported from the sunlight irradiation of propanil (200 mg/L) in distilled water were 3′-hydroxy-4′-chloropropionanilide, 3′-chloro-4′-hydroxypropionanilide, 3′,4′-dihydroxypropionanilide, 3′-chloropropionanilide, 4′-chloropropionanilide, propionanilide, 3,4-dichloroaniline, 3-chloroaniline, propionic acid, propionamide, 3,3′,4,4′-tetrachloroazobenzene and a dark polymeric humic substance. The photolysis products resulted from the reductive dechlorination, replacement of chlorine substituents by hydroxyl groups, formation of propionamide, hydrolysis of the amide group and azobenzene formation (Moilanen and Crosby, 1972). Tanaka et al. (1985) studied the photolysis of propanil (100 mg/L) in aqueous solution using UV light (λ = 300 nm) or sunlight. After 26 days of exposure to sunlight, propanil degraded forming a trichlorinated biphenyl product (<1% yield) and hydrogen chloride (Tanaka et al., 1985).
    Chemical/Physical. Hydrolyzes in acidic and alkaline media to propionic acid (Worthing and Hance, 1991) and 3,4-dichloroaniline (Sittig, 1985; Worthing and Hance, 1991). The half-life of propanil in a 0.50 N sodium hydroxide solution at 20°C was determined to be 6.6 days (El-Dib and Aly, 1976).
  • ShippingUN3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required.
  • IncompatibilitiesIncompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explo- sions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.
  • Waste DisposalHydrolysis in acidic or basic media yields the more toxic substance, 3,4-dichloraniline, and is not recommended.
Propanil Preparation Products And Raw materials
Propanil (709-98-8)Related Product Information
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