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ZSTK474

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ZSTK474 Basic information
ZSTK474 Chemical Properties
  • Melting point:217-219 °C(Solv: ethanol (64-17-5))
  • Boiling point:640.3±65.0 °C(Predicted)
  • Density 1.57
  • form White powder.
  • pka5.21±0.10(Predicted)
Safety Information
  • HS Code 29349990
ZSTK474 Usage And Synthesis
  • UsesZSTK474 is a triazine derivative that acts as an inhibitor of class I phosphatidylinositol 3-kinase (PI3K) isoforms (IC50s = 17, 53, and 6 nM for p110β, -γ, and -δ, respectively). It is selective for PI3K, as it has negligible activity against 139 other kinases when tested at 30 μM. ZSTK474 is orally bioavailable and shows strong antitumor activity against human cancer xenografts in mice. The efficacy of ZSTK474 against certain cancer cells and tumors can be enhanced by combination therapy.
  • DefinitionChEBI: A triamino-1,3,5-triazine that is 1,3,5-triazine in which two of the hydrogens have been replaced by morpholin-4-yl groups while the third hydrogen has been replaced by a 2-(difluoromethyl)benzimidazol-1-yl group. It is an inhibitor of phosphatidylinositol 3-kinase.
ZSTK474(475110-96-4)Related Product Information
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  • Company Name:Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd. Gold
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