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NVP-BEZ 235

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NVP-BEZ 235 Basic information
NVP-BEZ 235 Chemical Properties
  • Melting point:288-289°C
  • Boiling point:701.0±70.0 °C(Predicted)
  • Density 1.299
  • storage temp. Refrigerator
  • pka6.41±0.20(Predicted)
  • form White powder.
  • CAS DataBase Reference915019-65-7
NVP-BEZ 235 Usage And Synthesis
  • Chemical PropertiesLight Beige Solid
  • UsesA dual ATP-competitive inhibitor of PI3K and mTOR. p110α, IC50=4 nM; p110β, IC50=75 nM; p110δ, IC50=7 nM; p110γ, IC50=5 nM.
  • UsesInhibitor of phosphatidylinositol 3-kinases, P13K and mTOR.
  • UsesPhosphatidylinositol 3-kinase (PI3K) signaling through Akt/PKB and the mammalian target of rapamycin (mTOR) controls gene expression related to cell proliferation, differentiation, and apoptosis. Increased activity of this pathway is important in many types of cancer. NVP-BEZ235 is a potent dual inhibitor of PI3K and mTOR that is well tolerated, displays disease stasis when administered orally, and enhances the efficacy of other anticancer agents when used in in vivo combination studies. It inhibits PI3K isoforms and mutants with low nanomolar IC50 values, leading to growth arrest in the G1 phase. Through its effects on PI3K, NVP-BEZ235 inhibits VEGF-induced angiogenesis. By directly blocking cell growth and indirectly inhibiting angiogenesis, it has potential in both solid tumors and in metastatic melanoma therapy.[Cayman Chemical]
  • DefinitionChEBI: An imidazoquinoline that is 3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinoline substituted at position 1 by a 4-(1-cyanoisopropyl)phenyl group and at position 8 by a quinolin-3-yl group. A dual PI3K/mTOR inhibitor used in cancer treatment.
NVP-BEZ 235(915019-65-7)Related Product Information
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  • Company Name:ShangHai Biochempartner Co.,Ltd Gold
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