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Z-VAD-FMK

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Z-VAD-FMK Basic information
  • Product Name:Z-VAD-FMK
  • CAS:187389-52-2
  • MF:C22H30FN3O7
  • MW:467.49
  • EINECS:
  • Mol File:Mol File
Z-VAD-FMK Chemical Properties
  • Boiling point:732.4±60.0 °C(Predicted)
  • Density 1.214±0.06 g/cm3 (20 ºC 760 Torr)
  • Flash point:396.7℃
  • storage temp. -20°C
  • solubility DMSO: 20 mg/mL
  • form powder
  • pka11.05±0.46(Predicted)
  • color white
  • InChIKeyMIFGOLAMNLSLGH-QOKNQOGYSA-N
  • CAS DataBase Reference187389-52-2
Safety Information
  • Safety Statements 22-24/25
  • WGK Germany 3
  • HS Code 29145090
MSDS
Z-VAD-FMK Usage And Synthesis
  • UsesZ-VAD(OMe)-FMK is a cell-permeable, competitive, and irreversible inhibitor of all caspases. Through this action, it inhibits cleavage of poly(ADP-ribose) polymerase, preventing apoptosis when used at 10-50 μM. It also blocks caspase-mediated apoptosis in vivo. Z-VAD(OMe)-FMK effectively prevents caspase action in inflammasomes.[Cayman Chemical]
  • UsesZ-VAD-FMK is a caspase inhibitor that inhibits apoptosis and caspase processing in Jurkat T cells treated with low concentrations of z-FA-CMK.
  • General Description
    A cell-permeable, irreversible, pan-caspase inhibitor. Shown to enhance the freeze-thaw survival of human embryonic stem cells. Inhibits Fas-mediated apoptosis in Jurkat T cells. Also reported to inhibit Peptide: N-glycanse (PNGase) in vitro amd in vivo. When using with a purified recombinant enzyme, pretreatment with an esterase is required.
  • Biological ActivityCell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC 50 = 0.0015-5.8 mM). Active in vivo .
  • Biochem/physiol ActionsCell permeable: yes
  • Enzyme inhibitorThis tripeptide halomethyl ketone (FWfree-acid = 467.49 g/mol; Soluble to 9.35 mg/ml in DMSO; CAS RegistryNumber = 187389-52-2), also known as Z-VAD-FMK and caspase inhibitor VI, is a broad-spectrum caspase inhibitor that blocks caspase-mediated apoptosis. Z-VAD-FMK inhibits caspase processing (IC50 = 0.0015–5.8 mM, depending on enzyme and cell type). The aspartate methyl ester derivative (FW = 467.49 g/mol), also known as caspase inhibitor I, is far more cell-permeable. Target (s) : caspases; caspase-1; caspase-2; caspase-3; caspase-4 ; caspase 5; caspase-6; caspase-7; caspase-8 ; caspase-9; caspase-10.
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