2-Bromo-5-chloronitrobenzene

2-bromo-4-methylpropiophenone employed as an important intermediate for raw material for organic synthesis, agrochemical, pharmaceutical and dyestuff field. Specifically, this chemical can act as the intermediate in the synthesis of 4-methyl methcathinone HCl (mephedrone HCl or 4-MMC HCl), which is used as the sample for development and validation of a presumptive color spot test method for the detection of piperazine analogues in seizing illicit materials.

6280-88-2

41513-04-6

General procedure for the synthesis of 2-bromo-5-chloronitrobenzene from 4-chloro-2-nitrobenzoic acid: In a 25 mL round-bottomed flask, fitted with a Dimroth condenser (cooled to 10 °C), 4-chloro-2-nitrobenzoic acid (1.8 mmol), chloroisocyanuric acid ester, brominating agent and solvent (8 mL) were added. The reaction mixture was stirred and heated in an oil bath under fluorescent room light (FL) irradiation. Upon completion of the reaction, the cooled mixture was filtered through a short silica gel pad, washed with 1 M aqueous Na2SO3, dried over anhydrous Na2SO4, filtered and concentrated in vacuum to give 2-bromo-5-chloronitrobenzene. The product may contain 1-5% of 2-chloro-5-nitrobenzene as a by-product. The experimental results are detailed in Table 2. Table 2. Results of bromocarboxylation of nitroaromatic carboxylic acids