Rhynchophylline (10 and 30 mg/kg, i.p., once daily for 4 days) protects rats from pMCAO surgery induced ischemic brain damage[2].
Rhynchophylline (100 μM, 2 μL, injected bilaterally in the hippocamp) shows neuroprotective effects against Aβ1-42-induced neurotoxicity in rats[5].
Rhynchophylline (50 mg/kg, p.o., daily, 3-4 weeks) inhibits EphA4 activation in the hippocampus of APP/PS1 mice[6].
| Animal Model: | Aβ1-42(1.6 μM, 2 μL) treated rats[5] |
| Dosage: | 100 μM, 2 μL |
| Administration: | injected bilaterally in the hippocamp |
| Result: | Rescued the soluble Aβ1-42-induced spatial learning and memory deficits.
Inhibited Aβ1-42-induced excessive activation of extrasynaptic NMDARs.
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